| Desmin is an abundant cytoskeletal protein in skeletal muscle, forming intermediate filaments concentrated at the Z-disks of the sarcomeres. |
| Each cell contains smaller fibres known as myofibrils that house highly organized contractile units called sarcomeres. |
| All arthropod muscles seem to be striated, not obliquely striated or smooth, and the sarcomeres are of varying lengths. |
| Our hypothesis is that calpain 3 enhances CARP interactions with the sarcomeres thus preventing its passage and its nuclear activities. |
| Gradually, new sarcomeres are laid down to share the work load and reduce the wall stress. |
| The defective protein conforms abnormally theoretically disorganizing half of the cardiac sarcomeres and their ability to contract is abnormal. |
