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What is the opposite of having no effect?

Need antonyms for having no effect? Here's a list of opposite words from our thesaurus that you can use instead.

Verb
Opposite of present participle for to cause physical damage to
“He fired a shot at Superman, but it would have no effect against the man of steel.”
Verb
Opposite of present participle for to be fully understood, believed, or appreciated
Adjective
Having significant importance or value
“I'd like to think that the relationship we had was meaningful in some way.”
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