| The rate of development of tachyphylaxis to the pressor effect was found to be greater with pseudoephedrine than with ephedrine. |
| Indomethacin does not seem to show tachyphylaxis. |
| Total renal blood flow was not affected, and there were no signs of increased blood methemoglobin concentrations or tachyphylaxis. |
| With repeated administration every 12 to 24 hours, response becomes less effective due to tachyphylaxis. |
| Giving methotrexate concurrently, however, suppressed tachyphylaxis, probably by preventing the production of human antichimeric antibodies. |
| Once-weekly dosing might lessen the risk of side effects or tachyphylaxis, she noted. |
