| These are mutations frequently detected in oncogenes or tumour suppressor genes from human tumours. |
| This difference indicates a striking increase in selection against nonsynonymous substitutions in oncogenes and tumor suppressor genes. |
| Several genetic alterations to tumor suppressor genes have been shown to play a major role in tumorigenesis. |
| One variation of the baffled sound suppressor is known as the coaxial suppressor. |
| However, its potential function as a tumor suppressor gene suggests a possible role in the malignant transformation of mesothelial cells. |
| Thus, most hereditary cancer syndromes are the result of inherited mutations in tumor suppressor genes rather than oncogenes. |
