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What is self-annihilation?

What is self-annihilation? Here are some definitions.

Noun
  1. Annihilation by one's own act.
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Examples
Albion like Milton must tread the difficult way of self-annihilation and judgment.
As grandiose delusions go, global domination makes more sense than self-annihilation.
Given its many attempts at self-annihilation in the last century through its home-grown ideologies of fascism and communism, European guilt has a point.
As for me who pretended to nothing, I thought all succeeded well, inasmuch as all tended to self-annihilation.
So that the mystics are utterly wrong when they fancy that self-sacrifice can be attained by self-annihilation.
She feels immeasurably lost, a feeling which compels her to think of self-annihilation.

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