| Patient reported absent refractory period. |
| The refractory period sets a limit on the frequency at which action potentials can be conducted along single nerve fibres. |
| A direct positive inotropic effect and an increase in the refractory period also have been postulated as possible antiarrhythmia mechanisms of spironolactone. |
| Neither drug appreciably affects the duration of the absolute refractory period. |
| The alkaloid also acts on the myocardium to depress conduction and irritability, as well as to prolong the myocardial refractory period. |
| During refractory period, neuron does not change its potential. |
