The oldest antidepressants are the monoamine oxidase inhibitors, which were developed several decades ago. |
Eating DMT fails because monoamine oxidase in the gut metabolises the tryptamine into secondary compounds which lack any psychoactivity. |
The first antidepressant shown to be useful for SAD was the irreversible monoamine oxidase inhibitor phenelzine. |
Huh et al. 2005: Induced apoptosis in brain, increased efficiency of monoamine oxidases and increased level of caspase 3 and 12 in brain. |
As a nonselective inhibitor of monoamine oxidase, caution is recommended when used with adrenergic or serotonergic agents. |
Initial attention was drawn to hypericin and pseudohypericin since they inhibit the enzyme monoamine oxidase, as do several pharmaceutical antidepressants. |