Cationic drugs increase the risk for lactic acidosis by interfering with the renal tubular transport of metformin. |
Before the introduction of troglitazone in 1997 metformin was the only drug able to sensitise target tissues to insulin. |
Side effects of metformin include mild nausea, diarrhoea, and abdominal bloating. |
Currently, the first-line oral agents for type 2 diabetes are metformin and sulfonylureas. |
It is indicated for use as monotherapy or in combination therapy with metformin, a sulfonylurea, or insulin in the treatment of type 2 diabetes. |
Mice treated with paraquat and metformin survived significantly longer than those treated with paraquat only. |