Each epidermal melanocyte is associated with a group of neighbouring keratinocytes into which it transfers granules of pigment by way of long, branching dendrites. |
In lentigo maligna, the most frequent cell type is a spindled hyperchromatic melanocyte with scant cytoplasm. |
It is characterized by areas of melanocyte proliferation, and the hyper pigmentation of the epidermal basal cell layer in a linear fashion. |
An audience member asked about the possibility of melanocyte proliferation. |
A melanocyte can supply melanin to 35-40 keratinocytes. |
These phenotypic classes are discussed below, with reference to previously identified zebrafish melanocyte mutants. |