| The rationale for this treatment stems from the concept of nocturnal relative hypotonicity of the tear film. |
| In humans and rats, pregnancy-associated maternal plasma volume expansion and plasma hypotonicity may facilitate maternal-to-fetal water transfer. |
| It follows that hyponatremia almost universally indicates a state of hypotonicity. |
| Loss of equine hypertonic sweat is conducive to hypotonic plasma, and this hypotonicity inhibits voluntary water intake. |
| Hypotonicity was noted in all males at the high dose level. |
| Symptoms are related to the plasma hypotonicity that is secondary to water retention. |
