Whereas increasing temperature accelerated fluorescence depolarization, increasing solvent viscosity slowed the process down. |
In guinea pig airways, anandamide stimulates sensory nerves by inducing depolarization. |
In either case, there was no outward current through the channels during the depolarization. |
The depolarization opens the L-type calcium channels, causing inflow of calcium through the membrane into the cytosol. |
This induces electrical current in neurons, causing depolarization that then has behavioral effects. |
However, even with prolonged depolarization, only a fraction of stored neuropeptides, called the releasable pool, can be secreted. |