| These data confirm that cycloaddition occurs between the 8,9-double bond of HFQ and the 5,6-double bond of thymine. |
| As a second example, let us have a look at the gas-phase 1,3-dipolar cycloaddition of fulminic acid to ethyne. |
| The 1,3-dipolar cycloaddition of an alkyne with a nitrile oxide from the analogous alpha-chlorobenzaldoxime afforded the desired isoxazole. |
| Nitrone cycloaddition and retro-aldol reactions have also been applied to the total synthesis of morphine. |
| Heating induces crosslinking by 1,3 dipolar cycloaddition between an azide and an alkyne to give a 1,3 triazole linkage, resulting in a very stable structure. |
