Reserpine pre-treatment did not influence the positive chronotropic effect of pentoxifylline in rats. |
In the isolated, perfused rabbit heart, dolasetron and its reduced metabolite were equipotent in blocking the positive chronotropic effect of serotonin. |
This is referred to as chronotropic incompetence, which would have implications for intense training and endurance-related activities. |
Opioids mediate their chronotropic action through an effect on vagal efferents from the central nervous system. |
Intravenous salbutamol had approximately one-tenth the positive chronotropic potency of intravenous isoprenaline. |
Compared to orciprenaline, salbutamol was about 40 times less active in terms of inotropic effect and four times less potent in terms of chronotropic effect. |