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What is a biotransformation?

What is a biotransformation? Here are some definitions.

Noun
  1. (biochemistry) The changes (both chemical and physical) that occur to a substance (especially a drug) by the actions of enzymes within an organism
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Examples
However during this biotransformation process, generation of reactive metabolites might result in toxicity and liver cell damage.
Other recognized factors leading to medication allergy are pre-existing allergies and presence of diseases that interfere with medication biotransformation and excretion.
These results are in contrast with reports of enantioselective biotransformation in other species.
Methylation is not as important a route of biotransformation for exogenous chemicals as it is for endogenous chemicals.
Differences in placental membranes, placental transport and biotransformation all affect fetal exposure.
Altering the metabolism of and biotransformation processes for serotonin may be an important feature for the treatment of depression.

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