| Protein tyrosine kinases play fundamental roles in signal transduction pathways. |
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| He is an internationally recognized investigator in the areas of immunology, molecular biology, signal transduction and gene transcription. |
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| Could these gene products represent upstream components in a common signal transduction pathway such as a receptor or signal transducers? |
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| It is, in principle, possible that sphingosine could be involved in the regulation of gene expression and signal transduction. |
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| Protein kinases are enzymes that participate in signal transduction processes and, thus, in the control of cell growth. |
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| In recent years, signal transduction pathways controlling photoresponses in plants has been demonstrated. |
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| To study the biological effect of a new compound on signal transduction pathways, the target must first be validated. |
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| In addition to investigate the dynamic regulation of the modules during signal transduction, we also study their biogenesis. |
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| Before Pawson's pioneering work on signal transduction, it was generally not accepted that proteins could interact in such specific ways. |
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| Recombination can occur between exogenous DNA introduced into bacteria by conjugation, phage transduction, or DNA transformation and the bacterial genome. |
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| For example, problems include a low transduction of tumour cells because of their low expression of the Coxsackie adenovirus receptor required for adenoviral entry. |
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| Subsequently, a signal transduction cascade involving at least four plant hormones, ethylene, auxin, abscisic acid, and gibberellic acid, is activated. |
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| During transduction, potassium floods into the hair cell, depolarising the cell and triggering an action potential in the associated cochlear neurones. |
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| The binding of a chemical cue to an odorant receptor activates G proteins initiating a signal transduction cascade that results in a behavioral response. |
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| The transduction level of the tropism modified-virus will be increased toward the targeted cells by using the optimized ligand. |
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| The transduction of noxious stimuli begins with peripheral nociceptors. |
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| Signal transduction, the field pioneered by Dr. Greengard, is now a major focus of study. |
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| His research interests are in search by transduction and automatic adaptation to new environment. |
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| Genetically engineered organisms will not include organisms resulting from techniques such as conjugation, transduction and hybridization. |
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| There is, however, growing evidence that specific proteases may also act as mediators of signal transduction or effectors of programmed cell death during plant senescence. |
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| Neural networks can be seen biologically as a transduction signal pathway with no retroaction. |
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| Instead of conjugating, however, the bacteria exhibited another form of genetic exchange, genetic transduction. |
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| We describe major environmental cues resulting in hyponasty and briefly discuss their perception and signal transduction. |
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| The ossicles are three small bones in the middle ear which are involved in sound transduction. |
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| Molecules designed to block ATP from attaching to its binding domain will inhibit tyrosine phosphorylation and block signal transduction. |
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| Little is known about the components of signal transduction pathway that link these events. |
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| Regulation of taurocholate excretion by a hypoosmolarity-activated signal transduction pathway in rat liver. |
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| The overall process of receiving these messages and converting the information they contain into metabolic and physiological effects is known as signal transduction. |
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| Aegera's significant intellectual property assets and experience in apoptosis and signal transduction have driven the development of multiple therapeutic products for cancer treatment. |
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| The new results presented today complement Boehringer Ingelheim's additional progress in the fields of signal transduction inhibition and angiokinase inhibition. |
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| The infectious genome titer of MLV-derived vectors is determined using real-time quantitative PCR after transduction of indicator cells, using serial dilutions of the batch to be tested. |
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| The infectious genome titer is determined using real-time quantitative PCR, after indicator cell transduction using serial dilutions of the test batch. |
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| Each has a different transduction mechanism. |
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| Additionally, the delay of 20 30 min between aura and headache suggests that a time lag is required for the transduction of algesic signals beyond glia limitans via inflammatory mediators. |
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| Detectors include not only the component that senses the solutes but also those that perform the associated transduction, electronic amplification, and final readout. |
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| Nonetheless, it remains unclear whether these pathways comprise non-classical transduction components or include classical components, commandeered to elicit chemotropic responses. |
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| Although extensive works have been done in elucidating phytoalexin biosynthesis, UV stress signal transduction leading to accumulations of rice phytoalexin is largely unknown. |
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| Luteinizing hormone-releasing hormone-signal transduction and stathmin phosphorylation in the gonadotrope aT3-1 cell line. |
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| It aims at characterizing protein ligands of the tsetse fly, which bind to a trypanosome receptor, activating the signal transduction mechanism of the parasite. |
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| The aim of this study is to characterize tsetse fly proteins that bind to specific receptors at the trypanosome surface activating the signal transduction mechanism of the parasite. |
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| However, the accurate signal transduction mechanisms were not clear. |
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| By testing and evaluating the modulating effects of small molecules or known signal transduction protein complexes, researchers hope to create an alternative to current therapeutic approaches which inhibit essential enzymes. |
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| Better understanding of the roles of these scaffolds in signal transduction will aid in the development of more focused pharmacological interventions. |
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| The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycle kinase inhibition. |
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| Many of the diseases that we suffer from-like cancer, heart disease, and many mental disorders-essentially result from breakdowns in signal transduction through the specific protein interactions that Pawson identified. |
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| Dr. Branch's research also involves the study of signal transduction. He is interested in the Src family of protein tyrosine kinases and the SHP-1 protein tyrosine phosphatase. |
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| Boehringer Ingelheim's research efforts are focused on three main areas: angiokinase inhibition, signal transduction inhibition and cell cycle kinase inhibition, under which BI 6727 falls. |
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| Specific pharmacological approaches will then be taken to modify calcium dependent signal transduction and the outcomes of these procedures on secretion of toxins and viability of neurons will be determined. |
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| Investigation of the taste transduction mechanism has led to the development of bioassay specific proprietary intellectual property to facilitate the rapid identification of novel molecules. |
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| These span a broad spectrum of investigative arenas including food chemistry, taste transduction and genetics, ingredient development and instrumental analysis. |
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| Among their topics are redox signal transduction, carbon fixation in chloroplasts, plant mitochondrial metabolism, and photosynthetic carbon-nitrogen interactions. |
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| Using SVA, Thrasos has pioneered the design of compounds based on the structure of the bone morphogenetic protein family to activate the Smad transduction pathway. |
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| First, it is a monostratal model that does not require transduction. Hence it enjoys the full restrictiveness of finite state automata over transducers. |
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| Among the topics are the cell and its contents, metabolism, viruses, signal transduction and cellular communication, and blood coagulation and fibrinolysis. |
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| Protein kinases are a large group of related enzymes that activate many kinds of proteins, thus mediating signal transduction in cell growth and differentiation. |
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| Arazine is the first compound from Signum's novel anti-inflammatory platform to be commercialized from Signum's pipeline of Signal Transduction Modulators. |
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