| Further, the broken site at the TT4 gene contained a potential topoisomerase I cleavage site. |
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| ValstarTM is an anthracycline derivative which inhibits topoisomerase II, preventing DNA and RNA synthesis and associated tumour growth. |
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| In certain cases, the combination of a helicase and a topoisomerase provides a unique biological function and the interaction between the two is evolutionarily conserved. |
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| Among the genes affected by supercoiling are the topoisomerase genes. |
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| Recent studies in Xenopus have shown a role for DNA replication in the recruitment of topoisomerase II to the chromosomes to facilitate condensin assembly and condensation. |
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| Down-regulated topoisomerase II gene expression in etoposide-selected cells has also been shown to be associated with an increased rate of spontaneous polyploidization. |
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| An in vitro study showed that the collision between a moving replication fork and a stalled topoisomerase can convert the complex to a nonreversible form. |
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| Current topoisomerase inhibitors are potent, but may cause severe diarrhea as a side effect. |
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| As to segregation of replicated daughter molecules, to be discussed later, topoisomerase II is thought to locate DNA crossovers such as those present in catenated molecules. |
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| The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle. |
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| Finally, the in vivo catalytic activities of eukarytotic type IA topoisomerases, the topoisomerase III from various higher organisms may be related to their sequences. |
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| Mutations in topoisomerase genes of fluoroquinolone-resistant salmonellae in Hong Kong. |
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| Platinum compounds, antimetabolites and microtubule disruptors and topoisomerase inhibitors are often used for chemotherapy, usually in combination, and side effects can limit therapy. |
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| A hybrid topoisomerase comprising a DNA binding subunit of a type II topoisomerase from a Gram-negative prokaryote and an ATP-hydrolyzing subunit of a type II topoisomerase from S. aureus. |
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| In addition, a remarkable class of enzyme called DNA topoisomerase removes the helical twists by cutting either one or both strands and then resealing the cut. |
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| Quinolones have a bactericidal effect when these bind with two target enzymes, DNA gyrase and topoisomerase IV, which are essential for DNA replication within the cell. |
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| Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives. |
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