How to use synaptic in a sentence

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Sentence Examples In this case, spillover is limited to the postsynaptic sites under a single synaptic bouton, and occupancy is likely to vary across sites. Recently we have begun investigations of synaptic molecules up-regulated specifically during morphallaxis. But this is not to suggest that Hebb's influence was just his postulates related to synaptic change. Researchers believe these synaptic changes, called long-term potentiation or LTP, are the basis for learning in the brain. The correlation between changes in the kinetics of synaptic current and quantal amplitude remains strong for the corrected values as well. Such tendon jerks are tested as part of a routine neurological examination, to assess the state of synaptic connections. Regulation of glutamate reuptake occurs along with several forms of synaptic plasticity. When postsynaptic receptors are saturated, a quantum of synaptic current corresponds to the response evoked in a single synaptic bouton. The Torpedo electrocyte model has served to identify the most important components involved in synaptic transmission. The resulting synaptic inhibition is characterized by either a depressant or an excitant effect, depending on the population of cells involved. It diffuses across the synaptic cleft and binds to the end organ adrenergic receptor. A variety of experiments indicate that single synaptic connections exhibit a broad distribution of presynaptic release probabilities. From a screen of 24,000 mutagenized flies, 17 mutants with presynaptic defects in synaptic transmission were recovered. Depolarization of the presynaptic membrane causes release of acetylcholine into the synaptic cleft. Ed laughed lightly at catching her in her own synaptic misfire while she glared fierily at him. This is the release of a neurotransmitter into the synaptic cleft from synaptic vesicles in the axon terminal. A major type of neuron in the cerebral cortex may receive up to 10,000 synaptic connections from other neurons. This primary pathology includes a range of inflammatory disorders as well as neuronal loss along with dendritic damage and synaptic loss. Each little bump or spine on each dendrite is a synaptic connection from another nerve cell axon terminal. After synaptic transmission is blocked by botulinum toxin, the muscles become clinically weak and atrophic. Show More Sentences The only synaptic feedback to the pyloric pacemaker group through the EP to PD inhibitory synapse was removed by applying 10-5 M picrotoxin in the bath. In this study, we investigated the basic synaptic mechanisms responsible for reverberatory activity in small networks of rat hippocampal neurons in vitro. You can almost feel the charge of linking synaptic bursts as the trio generates a veritable Japanese garden of tinkles, clicks, rolls, and splashes. The stimulants promote the release of dopamine and norepinephrine from presynaptic neurons into the synaptic cleft but then block reuptake by these same neurons. The extrasynaptic receptors that are exposed to a much lower concentration of agonist and are not saturated may substantially enhance the quantal synaptic response. It means that your self is a very complex pattern of synaptic connectivity in your brain. The effects of reduced calcineurin levels on memory can be explained by a change in the plasticity of synaptic connections. Sleep allows the brain to renormalize this synaptic activity after it increases in the waking day. The acetylcholine molecules diffuse across the synaptic cleft and react with the acetylcholine receptors. First, diffusion of the neurotransmitter across the synaptic cleft takes approximately 0.05 millisecond. First, the neurotransmitter molecules simply diffuse out of the narrow synaptic cleft. The transmitter molecules are then expelled from the vesicles into the synaptic cleft. Third, they are metabolized into inactive compounds by enzymes in the synaptic cleft. Nerve impulses traveling down the axon reach the synapse and release neurotransmitters into the synaptic cleft, the tiny gap between neurons. A chemical that acts as a messenger between neurons, and is released into the synaptic cleft when a nerve impulse reaches the end of an axon. We will use chronic infusions of IL-l in organotypic hippocampal lices to examine the effects of IL-l on synaptic circuitry and neurogenesis. Amphetamine also induces effluxion of histamine from synaptic vesicles in mast cells and histaminergic neurons through. Most synaptic boutons in the mammalian central nervous system are too small to be investigated directly with electrophysiological tools on the single synapse level. A synaptic connection between a neuron and a muscle cell is called a neuromuscular junction. We emulate the synaptic functionalities such as long-term potentiation and depression. Show More Sentences The principal ganglionic neurons receive the synaptic output of the preganglionic motor fibers in the splanchnic nerves, which originate in the anterior horn cells. Emphasis will be placed upon the synaptic organization of the cortex, the generation of neurons and glia, and the behavioural sequelae. A computational account of these results is proposed, based on a unified model that combines chemotropic gradients and spike-time-dependent synaptic plasticity. In the case of motor neurons, the axon terminal finds the site of the original synapse on the muscle cell by recognizing the basal lamina that fills the synaptic cleft. Each neuron within it has tens of thousands of synaptic connections with other neurons. These are specialised molecules that cross the synaptic gap and stimulate the second nerve cell. Figure 6 illustrates how new synaptic connections are formed between neurons every hour or two of the basic rest-activity cycle. Hanson has shown that amphetamines increase the concentration of catecholamines in the synaptic cleft by stimulating their release from the interneuronal storage vesicles. As a nerve impulse, or action potential, reaches the end of a presynaptic axon, molecules of neurotransmitter are released into the synaptic space. At nerve terminals, stimulus-evoked calcium entry triggers transmitter release through rapid, regulated exocytosis of readily releasable synaptic vesicles. This local depolarization is known as an excitatory synaptic potential, and its amplitude is determined by the number of vesicles released from the presynaptic cell. Perhaps compose a fiction about hard-wired fictionalizing, a fiction that reminds readers of their synaptic deceptions. Axons travel from the neurons located in nuclei within the brain stem via the cranial nerves without synaptic interruption to the motor end plates on the striated muscle. When the spike reaches the synaptic terminals it causes neurotransmitters to be released into the synapse where they then flow to post-synaptic neurons. There this messenger molecule would activate appropriate genes needed to synthesize proteins that would permanently strengthen the synaptic connection. Brain slices preserve the brain architecture and thus are ideal for electrophysiological recordings to measure of synaptic strength and membrane excitability within a largely intact system. Study of the impact of polyunsaturated fatty acids on oxidative stress, dendritic pathology and synaptic function to the brain in Alzheimer's disease. In addition we also showed that these regenerated axons conduct action potentials and form functional synaptic connections with neurons across from the lesion site. We used PPF to test the hypothesis that TDE, galanthamine and ACh reduce synaptic responses by presynaptically depressing glutamatergic release. Adaptation to chronic PCP results in hyperfunctional NMDA and hypofunctional GABAA synaptic receptors. Show More Sentences This is what neuroscientists mean when they speak of the synaptic plasticity of synapses and it is generally thought to be the basis for most of our learning and memory. Neurone-specific enolase and creatine phosphokinase are protein components of rat brain synaptic plasma membranes. Long-term potentiation increases synaptic activity, while long-term depression reduces it. In both synaptic pathways, the relationships were roughly U-shaped. Legions of psychopharmacologists are pumping our new and improved anti-craving synaptic rejuvenator pills. Enhanced synaptic transmission in CA1 hippocampus after eyeblink conditioning. As for sick but still surviving nerve cells, it seems very unlikely that that their impaired synaptic functions could be restored to anything like normal levels in 10 minutes. Thus although each act of languaging will necessarily be dependent on the synaptic events occurring in the brain, one could not determine which language is being processed by studying the synaptic events alone. Hypocretin activation and synaptic innervation of the locus coeruleus noradrenergic system. Using this package every user can read the descriptions in his preferred language in all programs which use APT. This includes apt-cache, aptitude, synaptic, and various other. As these neurons begin to thrive, they re-establish physical connections to one another, building up a synaptic network not unlike that in the brain. Sleep is thought to decrease synaptic strength to a lower level, thus compensating for the net increase in synaptic strength that occurs during wakefulness. The mechanism acts as a synaptic gate that modulates the pain sensation from myelinated and unmyelinated peripheral nerve fibres and the activity of inhibitory neurons. In the brain, zinc is stored in specific synaptic vesicles by glutamatergic neurons and can modulate neuronal excitability. Importantly, overexpression of WASP in trc mutants and transheterozygotes of trc and Tsc2 suppressed their synaptic overgrowth phenotypes. That approach could theoretically be used to treat conditions like Alzheimer's: the beta amyloids that accumulate in the brain are thought to weaken synaptic connections, and, in so doing, inactivate certain memories. We reported homeostatic adaptations of synaptic plasticity in response to chronic cannabinoid or stress in vivo and unraveled a new substrate of cannabinoids effects in the extended amygdala. The Synaptic Therapies and Devices Group is focused on interrogating synaptic pathophysiology, with particular emphasis on the role of receptors and ion channels as potential therapeutic targets. This sets off a chain reaction of positive charges that carries the nerve impulse along the cell's axon to the synapse, where it releases neurotransmitters into the synaptic cleft. The transmission of nervous influxes from one cell to the next is done via the release of a chemical mediator into the space between the two cells, called the synaptic cleft. Show More Sentences Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. In the inner plexiform layer, the axons of the bipolar cells make connection with the dendrites of ganglion cells, once again at special synaptic regions. The presynaptic terminal is unmyelinated and is separated from the neuron or muscle cell onto which it impinges by a gap called the synaptic cleft, across which neurotransmitters diffuse when released from the vesicles. Thus, the ability to potentiate synaptic activity was specific to macroglial cells. One research focus is the characterization of the role of glycosyltransferases in the generation of glycoconjugates involved in neurogenesis, differentiation, synaptic function and neurodegenerative disease. Among those peptides known to affect synaptic transmission are substance P, neurotensin, somatostatin, vasoactive intestinal peptide, cholecystokinin, and the opioid peptides. A single neocortical neuron has 2500 connections at birth, but by age 2, it may have up to 15,000 synaptic connections. The typical synaptic cleft is about 0.02 micron wide. Synapsins are a group of neuronal-specific phosphoproteins that are important regulators of synaptic vesicle trafficing in presynaptic terminals. The focus will be to explore brain functions, from molecules to cognition, and brain dysfunction, from synaptic activity to neurodegeneration, as well as to gain a global understanding of the brain. Our results indicate that the astrocytic environment governs the number of NMDAR recruited during synaptic stimulation, thereby influencing the direction and magnitude of synaptic plasticity. When a nerve impulse reaches the end of the motor neuron, ACh is released from the presynaptic nerve ending into the synaptic cleft. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. Intracellular analysis of synaptic potentials induced in trigeminal jaw-closer motoneurons by pontomesencephalic reticular stimulation during sleep and wakefulness. It plays a key role in synaptic plasticity and so in learning. Once a stable baseline measure of electrical synaptic activity was obtained, LTP was induced by applying two separate stimulations of 100 hertz for 1 second, 5 seconds apart. Previous studies have shown that our ability to learn and form memories is due to an increase in synaptic communication called Long Term Potentiation. Examples from Classical Literature One thing remained, unasked and unbeknownst, grooved with synaptic permanence in their burgeoning brains. Time-travel always raises the synaptic delay threshold, but the trouble is it's so variable. A synaptic vesicle, about 42 nanometers wide, is loaded down with chemicals that serve as signals between nerve cells. The new model, published in the May 30 Science, reveals the roles of proteins in the synaptic bouton, a structure at the tip of a nerve cell's message-sending axon. Find more words! 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What is the adjective for synaptic? What is the noun for synaptic? Use our Sentence Generator Nearby Words synapsis synapsid synapses synapse synapomorphy synagogues synaptically synarthroses synarthrosis sync syncarpous syncategorematic 8-letter Words Starting With s sy syn syna synap synapt synapti