| A fourth target just over the horizon might be the promotion of local nitric oxide synthesis in bone by statins. |
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| From the perspective of the pharmaceutical industry, statins are an ideal group of drugs. |
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| It is evident from experimental animal studies and from human studies that statins have salutary effects in heart failure. |
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| Chronic use of statins has reduced thrombogenicity during PCI-induced plaque disruption and lessened distal embolization of microdebris. |
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| That trial used a unifactorial model for risk prediction and was undertaken before the introduction of statins. |
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| Adopting a mediterranean diet seems much more effective than statins in reducing the risk of cardiovascular disease. |
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| The results also imply that statins could help treat rheumatoid arthritis and other auto-immune diseases. |
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| With reduced levels of cholesterol, statins also inhibit the synthesis of bile acids. |
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| Health chiefs say that the level of cholesterol lowering drugs, statins, prescribed by GPs, has exceeded predicted levels. |
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| The current stars in this field are the cholesterol-lowering drugs known as statins. |
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| Use of aspirin and statins lowers C-reactive protein levels, but so does weight loss. |
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| In animals, statins increased the number of osteoblasts and new bone formation. |
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| The antioxidative properties of statins also prevent the development of cardiac and smooth muscle cell hypertrophy. |
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| The only known serious adverse effects of statins are rhabdomyolysis and liver failure from hepatitis. |
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| The dose of statins requires modification to attain LDL cholesterol levels that favorably effect endothelial function. |
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| Evidence suggests statins may reduce the risk of Alzheimer's disease and slow the course of multiple sclerosis. |
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| The research will be carried out in Glasgow, where the handing out of statins is most likely to happen, because of the city's abysmal heart attack record. |
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| This does not apply to the more recent statins, such as Lipitor, Crestor and Livalo. |
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| Diovan® should be given with other standard post-myocardial infarction treatment, including thrombolytics, aspirin and statins, as indicated. |
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| However, we now know that statins also reduce the production of A-beta from APP, so here is another promising future treatment strategy. |
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| The use of statins and aspirin is given prominence, as best founded in evidence. |
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| Already, America's most rotund citizens benefit from bypass surgery and cholesterol-lowering statins. |
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| All statins and fenofibrate are contraindicated in pregnant and nursing women. |
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| Genetic studies have led to the development of effective medication for treating hypercholesterolemia, namely statins. |
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| A recent study has shown that statins have a harmful effect on the metabolism of polyunsaturated fatty acids. |
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| The benefits associated with use of statins in primary prevention are less well defined. |
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| Various factors may increase the risk of myopathy and rhabdomyolysis with statins. |
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| Co-administration of ezetimibe and statins did not result in any new toxicities. |
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| So it made sense to see if fibrates also helped Type 2 diabetics who were taking statins. |
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| The risk reduction of 13 per cent with MICARDIS 80mg once daily was achieved despite patients receiving proven best standard of care therapies such as statins, antiplatelet agents, diuretics and beta-blockers. |
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| These data suggest that nanoparticulation is essential for cardioprotection of statins from IR injury in case administered at reperfusion. |
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| The study included 90 subjects with high and very high triglycerides as well as subjects on stable doses of statins. |
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| A rare side effect called myopathy, characterized by muscle degeneration, has been associated with a mutation in a gene involved in mediating liver uptake of statins. |
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| The third risk is that statins can definitely cause a condition called myopathy which is characterised by muscle pain and evidence of muscle damage on blood tests. |
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| More than 20 million Americans are taking statins, and by most estimates, at least 10 percent of them will experience some degree of muscle achiness or fatigue. |
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| Rather than special diets, he supports preventively taking approved anti-inflammatory medications, such as aspirin and statins, and scrupulously scheduling the standard vaccinations in order to prevent infections. |
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| We hypothesised that statins might also be activating endothelial genes that are athero-protective, and that are controlled endogenously by the transcription factor KLF2 when it is activated by haemodynamic forces. |
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| Likewise, there is evidence that statins can reduce the risk of venous thromboembolism, which is caused by a blood clot that breaks loose from within a vein and becomes caught in another vessel. |
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| Furthermore, indirect evidence is accumulating to suggest that the pleiotropic, antiinflammatory, and endothelial protective effects of statins may be an important determinant of their overall therapeutic benefit. |
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| The study was conducted by doctors from the Johns Hopkins University School of Medicine, Baltimore, Md. Their report indicated that 6.5 million older adults with low cholesterol but high CRP levels might benefit from statins. |
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| Even though the study's main endpoint was not met, it none-theless demonstrated generally good fenofibrate tolerance when administered alone or in combination with other agents including statins. |
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| Examples of statins found in fungi include mevastatin from Penicillium citrinum and lovastatin from Aspergillus terreus and the oyster mushroom. |
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| Comparisons to simvastatin in patients with dyslipidemia at high risk of coronary heart disease showed the two statins to be equivalent. |
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| Other explanations offered include the suppression of coenzyme Q10 production, as well as the pleiotropic effects of statins. |
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| For a total of 2,830 employees, copayments for statins were eliminated and the co-payment for clopidogrel was significantly reduced. |
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| Manufacturer package inserts have started indicating that statins should be used at a low dose when combined with gemfibrozil. |
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| In laboratory experiments, phagocyte blood cells that kill and ingest foreign invaders became more effective after being exposed to statins. |
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| This new group of people who are now eligible for treatment will be taking statins for primary prevention, i.e. to prevent the development of cardiovascular disease. |
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| While statins have been identified as potential teratogens on the basis of theoretical considerations and small case series, the available evidence is far from conclusive. |
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| The statins segment comprises combined market revenue of statin drugs such as atorvastatin, fluvastatin, rosuvastatin, pravastatin, simvastatin, pitavastatin, and lovastatin. |
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| Although statins are effective in reducing heart attack risk, many users still often have high levels of triglycerides and go on to have heart attacks. |
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| Researchers at the University of Edinburgh have shown the therapeutic potential of statins to treat patients with an inflammatory lung condition known as bronchiectasis. |
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| These lipophobic statins are reluctant to dissolve into cell membranes. |
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| The clinical studies have included short and long-term, placebo-controlled and comparative studies versus statins, fibrates, acipimox and probucol. |
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| Drugs affected by grapefruit juice, where there is a clinically significant risk, include the statins, felodipine and other calcium antagonists, cyclosporin, and amiodorone. |
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| Statins are a group of drugs used for lowering the levels of LDL cholesterol in the body. |
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| Statins modify patients' lipid profile and lower their risk of coronary heart disease. |
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| Statins have become so critical in the war against cholesterol that a leading statin researcher compares them to the ultimate miracle med. |
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| Statins were found to be safe, with minimal or no significant increase in liver function test abnormalities or elevation of creatine kinase levels. |
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| Statins alone often don't get LDL levels into the safe range for those people. |
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