How to use platelet in a sentence

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Sentence Examples However, it may be a sign of platelet or vascular disorders and is common in leukaemia and HIV infection. Three patients had low platelet counts before discharge from the first hospitalization. The patient subsequently received platelet and red blood cell transfusions. Unfortunately, despite this precaution, the hazards of platelet transfusion still include serious septic reactions. The sulfide metabolite of sulfinpyrazone affects platelet aggregation by inhibiting thromboxane production. As a platelet is activated it can release ADP and thromboxane, both potent autocatalytic molecules. An IV bolus of 3-5 g arginine reduced blood pressure and platelet aggregation in patients with type 1 diabetes. Serotonin is a vasoconstrictor and uses agonists, such as ADP, epinephrine, and norepinephrine, to promote platelet aggregation. They found a peptide in urine from autistics that increased platelet content of serotonin, which is also a common finding in autism. For example a blood stem cell will go on to become a red blood cell, platelet or white blood cell. It inhibits platelet clumping and enhances fibrinolytic activity, therefore, prolonging bleeding and clotting times. The combination of tocopherols has a synergistic platelet inhibitory effect. Twenty-four percent of patients had platelet counts above the upper range of normal. Recent studies show that ibuprofen interferes with the effect of aspirin on platelet aggregation. They are currently particularly looking for platelet donations as these only have a shelf life of five days. The platelet structure of the reinforcing fillers in nanocomposites may offer improvement in barrier properties of the polymer compound. Taking aspirin with dipyridamole reduces platelet accumulation at the anastomosis. With regard to fibrinogenic activity, it was determined that the garlic inhibited platelet aggregation. In addition to the severe anemia, aplastic crises also may lead to decreased white cell or platelet counts. A number of rare or uncommon congenital syndromes are associated with decreased platelet production. Show More Sentences These patients may warrant periodic review of hemostatic parameters, especially platelet counts. The wound is then filled by a blood clot containing platelet aggregates, red blood cells, and white blood cells trapped in a fibrin meshwork. Aspirin also reduces endothelial cell production of prostacyclin, an inhibitor of platelet aggregation and a vasodilator. Mice fed a control diet consisting of mouse chow and no additional supplementation experienced irreversible platelet damage and premature death. There is also impairment of the platelet response to thrombin, collagen, fibrinogen, and von Willebrand factor. The vascular effects result in tissue ischemia from vasoconstriction, platelet aggregation, and increased blood viscosity. Morphological changes in platelets were monitored by automated haematological cell counter for platelet count and mean platelet volume. Some hematology instrumentation prints the red cell and platelet histograms as part of the report. Nitric oxide, a principle physiological dilator, produces local vasodilatation and inhibits platelet adherence and aggregation. Dextrans can decrease platelet adhesiveness, serum fibrinogen, and other factor levels to cause bleeding. Compressive force on the platelet, on the other hand, is a function of both the incident angle and shear rate. Purpura may be secondary to thrombocytopenia, platelet dysfunction, coagulation factor deficiency or vascular defect. Splenomegaly or giant hemangioma can result in thrombocytopenia because of platelet sequestration. Only the parent acetylsalicylic acid has any significant effect on platelet function. The authors used a platelet function analyser that timed platelets aggregating into a plug big enough to close a small hole in a membrane. These substances activate white blood cells, increase platelet activation and aggregation, and cause vasoconstriction. Fibrin and platelet thrombi were prominent in the lumina of the vessels and in the space beneath the endothelium. Coagulation factors circulate as zymogens and platelet procoagulant surfaces are internalized. The most serious side effects include gastrointestinal bleeding and perforation, renal dysfunction, and platelet dysfunction. He was treated with blood and platelet transfusions and discharged eight days later with a modest improvement in peripheral blood count. Show More Sentences Your child may need blood and platelet transfusions frequently. She was treated with plasmapheresis and platelet transfusions. This rapid platelet decrease suggests an anamnestic response. This platelet release reaction and aggregation lead to the recruitment of many other platelets to the vessel wall with the formation of a hemostatic platelet plug. Indicated tests include a complete blood cell count with platelet count, a peripheral blood smear, and prothrombin and activated partial thromboplastin times. Actin and other contractile proteins within the pseudopods of platelets produce platelet retraction that prevents further blood loss and facilitates healing. Previous transfusions may sensitize patients to foreign platelet antigens. Cilostazol blocks the activity of the enzyme phosphodiesterase which induces platelet aggregation and prevents the degradation of cyclic adenosine monophosphate. Following IVIG therapy in patients with ITP, platelet counts generally rise, apparently by Fc receptor blockade of splenic phagocytes and other reticuloendothelial cells. This literature mainly comprises the variation in genes for blood coagulation factors, inhibitors, fibrinolytic factors and platelet membrane receptors. A lifelong bleeding diathesis may suggest a congenital platelet dysfunction, but an onset in adulthood does not necessarily exclude a congenital problem. These include arteriovenous shunts, giving rise to congestive heart failure, bleeding diathesis due to platelet consumption, and massive hemoperitoneum resulting in rupture. It may also improve microcirculation and reduce platelet aggregation. Hemostasis involves the integration of many procoagulant proteins, natural anticoagulants, fibrinolytic proteins, and platelet surface glycoproteins. Levels of platelet calmodulin for the prediction of progression and severity of adolescent idiopathic scoliosis. Ticagrelor is a platelet inhibitor indicated for reducing the rate of throm-botic events in patients with acute coronary syndrome. Could mean platelet volume among complete blood count parameters be a surrogate marker of metabolic syndrome in prepubertal children? Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. We found that pro-death Bcl-2 family proteins were not required for platelet formation from megakaryocytes. In platelet agregometer test, GT platelets do not aggregate following interaction with any substance except for ristocetin. Show More Sentences Influence of 3, 4', 5-trihydroxystibene-3-mono-D-glucoside on vascular endothelial epoprostenol and platelet aggregation. Normal platelet counts range from 150,000 to 450,000 per microlitre of blood. Other, more subtle signs include spider angiomas, reddening of the palms, declining platelet counts, or a family history of liver disease. Bernard-Soulier syndrome lacks a platelet response only for ristocetin and is associated with thrombocytopenia and giant platelets. In late hemorrhagic cases, high and sustained viremia, severe platelet loss and poor immune response were often cited as causes of death. Because garlic might reduce platelet aggregation, people taking anticoagulant medication are cautioned about consuming garlic. Dual effects of sulfated D-galactans from the red alga Botryocladia occidentalis preventing thrombosis and inducing platelet aggregation. Pentoxifylline is a drug that inhibits platelet aggregation and reduces blood viscocity by a variety of mechanisms, improving microcirculation. It is a special centrifuge which is preferred for the preparation of platelet products to treat patients who lack thrombocytes. Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. A simple technique to determine thrombopoiesis level using immature platelet fraction. Effects of lithium on thrombopoiesis in patients with low platelet cell counts following chemotherapy or radiotherapy. Clinically apparent atherosclerotic disease in diabetes is associated with an increase in platelet microparticle levels. Generally a unit or single donor platelet product equals a pint or a transfusable amount,'' Nicely said. We utilize several different therapies to optimize platelet function and bleeding time. Since late 2007, the patient had developed mild macrocytic anaemia with a borderline low platelet count. Current therapies for ITP include steroids, blood platelet production boosters and splenectomy. Atherothrombotic events due to vasoactivity, inflammation and also lipids may affect platelet function. Platelet response to cyclic nucleotides is complex and depends on nucleotide concentrations and the timecourse of platelet exposure. One of the CTAD syringes was precooled to minimize in vitro platelet activation, degranulation, and formation of microparticles. Show More Sentences Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenol. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. Studies showed a low WBC with predominant lymphocytes, a low platelet count, and a falling hemoglobin level, all attributed to hypersplenism. The results of platelet aggregometry and haemolysis substantiate the same where high work of adhesion exhibiting surfaces have fared poorly. Essential thrombocytemia is a rare myeloproliferative disease characterized by a persistent increase in platelet numbers and platelet dysfunction. The risk of severe bacterial infection is estimated, as of 2002, at about 1 in 50,000 platelet transfusions, and 1 in 500,000 red blood cell transfusions. To the best of our knowledge this is a novel finding, which may lead to further insight in how megakaryocyte maturation and platelet production change with age. In experimental studies, platelet aggregation, mastocyte degranulation and histamine secretion have been shown to occur after trigeminal ganglion stimulation. Aspirin inhibits platelet aggregation by blocking cyclooxygenase in the archidonic acid pathway, which inhibits the formation of thromboxane A2 in platelets. Mean platelet volume in patients with isolated coronary artery ectasia. His hematoxylin-eosin-stained blood smear confirmed markedly decreased platelet and leucocyte counts, accompanied by normochromic normocytic red cells. The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood. They investigated mean platelet volume in patients with idiopathic cardiomyopathy and ischemic CMP and compared these values with those of the controls. Recovery of normal haemostatic function may be accelerated by giving fresh whole blood, fresh frozen plasma, cryoprecipitates or platelet concentrates. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. The proposed method was applied to the motions and deformations of a single RBC and multiple RBCs, and the thrombogenesis caused by platelet aggregation. Anna Children's Hospital and the University of Vienna, Austria, will present data on the safety and efficacy of INTERCEPT platelet transfusions in immunocompromised children. Many pre-formed mediators are involved in an anaphylactic reaction, including histamine, tryptase, chymase, mast cell carboxypeptidases, platelet activating factor and others. This platelet-rich substance is called a buffy coat and will be combined with three others from donors of the same blood type to make up one platelet donation. A decrease in red and white blood cell count and thrombocytes after the procedure was observed, and 3 patients needed blood transfusions or platelet infusion. Examples from Classical Literature A single platelet lying upon a red corpuscle may easily be mistaken for a malarial parasite. When the bruising failed to subside Thea, 37, was at first told by doctors she had a blood platelet disorder. Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease. People with platelet clumping have an antibody in their blood that recognizes these changes, binds to the platelets, and provokes clumping. Find more words! 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Words that rhyme with platelet What is the plural of platelet? What is the noun for platelet? Translations for platelet Use our Sentence Generator Nearby Words platelayer plate-glass platefuls plateful plated plate boundary platelets platelike platen platens plater plateresque 8-letter Words Starting With p pl pla plat plate platel platele