How to use phosphorylation in a sentence

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Sentence Examples As expected, casein phosphorylation occurred on serine and threonine residues. Within skeletal muscle and heart activation of AMPK leads to the phosphorylation and inhibition of acetyl-CoA carboxylase. Changing the phosphorylation state of the CTD is one mechanism by which binding of accessory proteins to the CTD of pol II may be regulated. Smooth muscle does not contain troponin and is primarily regulated by the phosphorylation of myosin. In animal cells serine, threonine and tyrosine are the amino acids subject to phosphorylation. Cytochrome oxidases are the terminal enzymes of aerobic electron transport phosphorylation. Subsequent binding of the regulatory protein arrestin follows this phosphorylation. Soluble proteins were extracted from gravistimulated pulvini and subjected to protein phosphorylation reactions. Protein kinases turn on other enzymes by a chemical reaction called phosphorylation that adds phosphate tags to proteins. Dynamic control of protein phosphorylation is necessary for the regulation of many cellular processes, including mitosis and cytokinesis. We can divide cellular respiration into three metabolic processes: glycolysis, the Krebs cycle, and oxidative phosphorylation. There are two processes that occur within the mitochondria named as the kerbs cycle and oxidative phosphorylation. A general mechanism of toxicity may include, for example, substances that uncouple oxidative phosphorylation. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Adenosine monophosphate formed by phosphorylation of adenosine is incorporated into the high-energy phosphate pool. Phosphate is necessary for the generation of adenosine triphosphate from adenosine diphosphate and adenosine monophosphate and other crucial phosphorylation reactions. Fig. 1 Schematic illustration of mammalian oxidative phosphorylation system. Erlotinib potently inhibits the intracellular phosphorylation of EGFR, which is expressed on the cell surface of normal cells and cancer cells. This model predicts that upregulated 14-3-3 causes abnormal tau phosphorylation, tau aggregation, microtubule disruption, and neurodegeneration. Our interest in cellular processes regulated by phosphorylation events also involves the use of cutting-edge proteomics technologies. Show More Sentences However it is still not clear how tau phosphorylation is regulated in the normal brain. Protein phosphatase inhibition results in a shift in the balance towards higher phosphorylation of target proteins. Next we examine how multisite phosphorylation of key phosphoproteins in the various feedback loops influence dynamical behaviors using the random parameter search method. The phosphorylation levels were detected with antiphosphorylated antibodies by Western blot analysis. Their antiviral effect is dependent on the phosphorylation of viral thymidine kinase. Chemical modifications of these basic amino acid residues include methylation, phosphorylation, and acetylation. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. In mitochondria, it is found in cytochrome c oxidase, which is the last protein in oxidative phosphorylation. Molecules designed to block ATP from attaching to its binding domain will inhibit tyrosine phosphorylation and block signal transduction. Survival of metazoan organisms is dependent upon their ability to generate energy through the process of mitochondrial oxidative phosphorylation. The ubiquitination system differs in one key way from the methylation and phosphorylation timing operations we mentioned above. In rat striatal synaptosomes METH-stimulated DAT T53 phosphorylation was rapid, occurring within 60 sec. This result suggests that 14-3-3 plays a central role in regulation of tau protein phosphorylation in normal brain. 14-3-3 expression has been reported to be upregulated in the AD brain. The final stage is the conversion of the chemical energy in NADH and FADH2 formed in the second and third steps into ATP by a process known as oxidative phosphorylation. This part of oxidative phosphorylation is called electron transport. Mitochondrial complexes for oxidative phosphorylation. The parties have further argued that BASF enjoys patent protection for the active ingredient Chlorfenapyr, which according to the parties is a pyrazole analog uncoupler of oxidative phosphorylation. Oxidative mitochondrial function: the principal function of the mitochondrion, in bringing the final phase of aerobic metabolism to a close: oxidative phosphorylation. Luteinizing hormone-releasing hormone-signal transduction and stathmin phosphorylation in the gonadotrope aT3-1 cell line. We study regulatory processes such as receptor phosphorylation, palmitoylation, ubiquitination and endocytosis that control hormonal responsiveness under normal and pathological conditions. Show More Sentences We have also determined SASH1 does not normally have tyrosine phosphorylation in HeLa cells. Although, the mechanism of drug action on DAT is unclear, DAT phosphorylation is associated with altered surface expression and DAT activity. The phosphorylation of Histone H3 at serine residue 10 by Msk1 during interphase marks transcriptional activation. Thus, the mitochondria, which produce most of the cell's ATP, contain all of the enzymes needed to carry out the tricarboxylic acid cycle and oxidative phosphorylation. Approaches to finding the molecular basis of mitochondrial oxidative phosphorylation disorders. Using inhibitors to the members of MAPK and PIKK, we also determined the protein kinases responsible for asbestos-induced p53 phosphorylation. Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol. To establish this link, the investigators are studying the role of Aß-related peptides in the phosphorylation of tau protein and its relationship, if any, to the loss of cholinergic neurons in primary rat septal cultures. The fatty acids are broken down into smaller molecules that can enter the citric acid cycle for the synthesis of ATP by oxidative phosphorylation. These involve protein interactions and phosphorylation events. In summary, this work contributed for a better understanding of the role of FGF signaling during myogenesis, and discovered a novel mechanism of FGF receptor phosphorylation. The resulting time activity curves are then fitted with a tracer compartment model or submitted to graphical analysis in order to derive the phosphorylation of18 F-2-deoxyglucose. It was here I began my first physiology experiments with rat atria, where I measured the strength of atria contraction and the degree of phosphorylation of contractile proteins. In isolated cases the effect of phosphorylation is well known, but what is still not clear is the overall picture of the regulatory and control system of all cells. Three modulated pathways, C21-Steroid hormone metabolism, oxidative phosphorylation, and metabolic pathways, are associated with metabolism, indicating the basal metabolism of cells in testis are affected. We also propose that hyposialylation would dampen the phosphorylation level of the MET receptor and, therefore, result in the disengagement of its downstream pathways. Juglone treatment resulted in the accumulation of pThr53 suggesting a role for Pin1 in regulating rDAT T53 phosphorylation and thereby its function. Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstem. We exposed C6 cells to TFSA to examine the effects of TFSA on the cell viability and the expression and phosphorylation of key proteins in the ERK and PI3K signaling pathway. It consists in a phosphorely in which phosphorylation of CheY by CheA results in the interaction of CheY with the flagellar rotor and changes in flagella rotation. Show More Sentences Analyses of double phosphodeficient mutants proved that the availability of even one out of three phosphorylation sites is sufficient for the feedback monomerization to occur. The result is consistent with the idea that PGO is interacting with an amino acid residue that lies in the vicinity of the phosphorylation site, Aspas. One of these alkaloids, called harmine, inhibits a protein known as DYRK1A, which has been implicated by this and other studies in the formation of tau phosphorylation. Phosphorylation spectra are not disturbed by photolysis signals because photolysis is complete before recording of the first spectrum used in the subtraction. Phosphorylation of proteins is central both to direct regulation of activity and to protein-protein interactions. Phosphorylation of both acetyl CoA carboxylase and AMP-activated protein kinase was increased, thus explaining the increase in fatty acid oxidation. Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Seri57 in intact human platelets correlates with fibrinogen receptor inhibition. Find more words! 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What is the adjective for phosphorylation? What is the noun for phosphorylation? Use our Sentence Generator Nearby Words phosphorylated phosphoryl phosphorus cycle Phosphorus phosphorus phosphors phosphotyrosine phot photic photic zone photinia photo 15-letter Words Starting With p ph pho phos phosp phosph phospho phosphor phosphory phosphoryl phosphoryla