| Loss of p53 control leads to uncontrolled growth and is associated with more aggressive tumours. |
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| For example, a severe sunburn with peeling skin shows p53 in action causing programmed cell death of the skin. |
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| For biliary duct cancers, p53 gene mutation is an important contributor to carcinogenesis. |
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| The CGL1 cell line has functional p53 even though these cells express the E6 oncoprotein. |
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| Destruction of the proteins essentially cripples p53 and opens the door to malignant transformation. |
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| Alterations in the p53 gene are the most common genetic defects known to occur in human tumours. |
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| The researchers also speculated that disturbances in p53 may also play a role in some forms of Parkinson's disease and amyotrophic lateral sclerosis, or Lou Gehrig's disease. |
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| The wild-type P53 protein is a nuclear phosphoprotein coded by the P53 tumor-suppressor gene. |
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| Using inhibitors to the members of MAPK and PIKK, we also determined the protein kinases responsible for asbestos-induced p53 phosphorylation. |
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| Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. |
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| Direct p53 binding followed by conformational changes appears to be a mechanism by which mutant p53 is depleted. |
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| Degradation of p53 by human Alphapapillomavirus E6 proteins shows a stronger correlation with phylogeny than oncogenicity. |
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| The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. |
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| Recently it has been suggested that basal tumors are enriched for p53 nonsense and frameshift mutations. |
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| A decade ago, histone acetyl transferases were first reported to acetylate the tumour suppressor p53, leading to the notion that HATs and HDACs are not just for histones. |
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| As cells become damaged and precancerous, the p53 protein prevents those cells from continuing towards becoming tumors by causing the cells to senesce. |
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| Agami found that the protein BRD7 activates P53 and could therefore suppress the development of cancer. |
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| Until now, even though ARF was known to be expressed in some tumors with mutated p53, ARF largely was thought to be nonfunctional in this scenario. |
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