| Although shelters likely altered other, unquantified microenvironmental variables, experimental units were affected equally. |
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| Variability among colonies includes developmental, microenvironmental, teratological, plus macroenvironmental and genetic differences between colonies. |
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| Restoration of normal microenvironmental signaling can reverse the malignant phenotype even though the cancer cells retain all of their neoplastically transforming mutations. |
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