How to use kinase in a sentence

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Sentence Examples High levels of intracellular calcium allow calmodulin to activate the myosin light chain kinase that facilitates muscle contraction. A DNA substrate containing a thymidine kinase gene fused to a neomycin-resistance gene was stably integrated into cells. Creatine kinase is an enzyme that is found in striated muscle and tissues of the brain, kidney, lung, and gastrointestinal tract. This flavoprotein is a serine-threonine protein kinase able to phosphorylate its serine and threonine residues. This would produce an amino-terminal truncated protein, lacking an essential subdomain required for protein kinase activity. Concentrations of serum creatine kinase, transaminases, urea, and creatinine may be raised, and bicarbonate may be reduced. This receptor kinase can recognize a structure on bacterial pathogens called flagellin that makes the bacteria motile. Recent antitumor research has been focused on tyrosine kinase growth factor receptors. It is going to lead to increases in the appearance, of proteins, such as creatine kinase in the bloodstream. We established transgenes, allowing conditional expression of the mutant kinase under control of the heat-shock promoter. This conversion is catalyzed by the ATP requiring enzyme, pyridoxal kinase. Colored lines connect histidine kinase and response regulator proteins belonging to the same signaling pathway or species phyletic cluster. Two of these, adenylate kinase and purine nucleoside phosphorylase, contain potential critical building blocks. They may also serve as upstream activators of the protein kinase C, which is involved in cell wall biosynthesis. This messenger in turn activates a so-called kinase, an enzyme that attaches phosphate groups to other proteins. Two intracellular enzymes that may support active ion transport across crustacean gills are carbonic anhydrase and arginine kinase. The oligo primer was end labeled using T4 polynucleotide kinase. It is this cAMP that activates cAMP-dependent protein kinase, or PKA, that phosphorylates various cardiac ion channels in the sarcolemma and within the sarcoplasmic reticulum. Normal cellular thymidine kinase does not effectively utilize acyclovir as a substrate. Thus, new pharmacological assays were developed, of which 40 in the sole kinase family of assays and 7 new chemical libraries. Show More Sentences Our multi-targeted kinase program continues to advance with the goal of identifying a clinical candidate over the next 3-9 months. His work there focused on the MAP kinase signalling pathway and the mechanisms by which mitogenic cues promote cell growth and proliferation. We have recently identified novel molecular mechanisms regulating the Polo kinase during the cell cycle in the fly. Statins were found to be safe, with minimal or no significant increase in liver function test abnormalities or elevation of creatine kinase levels. The interconversion of the bifunctional enzyme is catalyzed by cAMP-dependent protein kinase, which in turn is regulated by circulating peptide hormones. A kinase inhibitor binds to the kinase domain much as a key fits into a lock. Thus mutant cells are able to proliferate in the presence of TFT, whereas normal cells, which contain thymidine kinase, are not. He said another gene, cyclin-dependent kinase inhibitor 2A, seemed to be involved in cancer, diabetes and heart disease. Where applicable, these sentences are further marked with phosphorylated protein, kinase, site, interactant, type of interaction and effect. Thymidine kinase proficient cells are sensitive to TFT, which causes the inhibition of cellular metabolism and halts further cell division. The most common adverse event related to telbivudine was elevation of creatine kinase. On admission his heart rate and serum creatinine and creatine kinase levels were elevated. We are currently interested in the regulation of the Polo kinase, a central coordinator of mitosis and cytokinesis. Daptomycin is associated with myositis, which requires monitoring of creatine kinase for patients on therapy. Xalkori blocks the growth of tumours caused by a mutant form of the gene which encodes a signalling molecule known as anaplastic lymphoma kinase. These include AC220, a kinase blocker for treating an acute form of leukaemia. A failed transcription-factor gene is as common a cause of cancer as a failed kinase gene. The most widely accepted and significant leukemogenic mechanism attributed to the fusion protein involves the constitutive stimulation of tyrosine kinase. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. Their antiviral effect is dependent on the phosphorylation of viral thymidine kinase. Show More Sentences For example, cells transduced with the herpes simplex thymidine kinase gene die when treated with gancyclovir, a drug already available on the market. Considerable effort is directed toward the expression of proteins from mammalian MAP kinase pathways as well as from the yeast pheromone pathway, which provides an excellent model of a MAP kinase signaling system. Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. These include kinins like PKC and tyrosine kinase, TNF, NF-kappa B, cyclic D, protein API, STAT family agents, etc. Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster-specified thymidine kinase. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Rsp5Bul2 physically interacts with cohesin and the Mec1 kinase, thus promoting checkpoint-dependent cohesin ubiquitylation and cohesin-mediated fork protection. But it also turned out to inhibit another kinase receptor called c-kit, which is overexpressed in gastrointestinal stromal cancer, as well as abl, the internal kinase whose gene goes awry in chronic myelogenous leukemia. Herein, we review candidate blood protein biomarkers including extracellular-regulated kinase, phosphoinositide 3-kinase, matrix metalloproteinase 9, amyloid-beta and amyloid-beta protein precursor. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. Herpesvirus-specified thymidine kinase transforms acyclovir to its monophosphate which is then transformed by cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. The selective toxicity of cladribine towards certain normal and malignant lymphocyte and monocyte populations is based on the relative activities of deoxycytidine kinase, and deoxynucleotidase. In around a quarter of patients presenting the most common form of leukaemia, namely acute myeloid leukaemia, this kinase is impaired and constitutively active, enhancing proliferation of haematopoietic cells. Thus, further modifications of carbocyclic thymidine analogs represent a good strategy for developing more powerful thymidylate kinase inhibitors. Cytokinin controls the cell cycle at mitosis by stimulating the tyrosine dephosphorylation and activation of p34cdc2-like HI histone kinase. Aurora kinase B also phosphorylates Ser10, along with Ser28, at the onset of mitosis to initiate chromosome condensation. Use of diacylglycerol kinase to quantitate picomole levels of 1,2-diacylglycerol. It is postulated that cells with high deoxycytidine kinase and low deoxynucleotidase activities will be selectively killed by cladribine as toxic deoxynucleotides accumulate intracellularly. The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycle kinase inhibition. Show More Sentences Boehringer Ingelheim's research efforts are focused on three main areas: angiokinase inhibition, signal transduction inhibition and cell cycle kinase inhibition, under which BI 6727 falls. While immunoprecipitated Tb670 protein possesses protein kinase activity, the activity under normal culture conditions is modest. Diagnosis is confirmed by testing the blood levels of creatine kinase, an enzyme released from degenerating muscle, and also by electromyography and muscle biopsy. He did this by correlating tackles and collisions against known indicators of skeletal muscle damage, like the hormone cortisol and the protein creatine kinase. Cardioprotective effects of niacin were shown by decreased release of creatine kinase, and improved coronary blood flow and cardiac contractility. Just so we're in the same ballpark, when I refer to Avastin or bevacizumab, I'm talking about the same class of new antiangiogenics or tyrosine kinase inhibitors that Dr. Knox was talking about with Sutent. A new medicine that may help to extend survival is an inhibitor of tyrosine kinase, an enzyme involved in signal transduction in many types of tumour cells. We already showed that this approach is valid as we identified one new substrate of BACE 1, namely the protein tyrosine kinase Ephrin A8 receptor. Serotonin begets cyclic AMP, which begets protein kinase A, and so forth. In 1999, Aventis, a large pharmaceutical firm based in Frankfurt, launched a program aimed at discovering kinase inhibitors through structure-based drug design in a bid to make better use of genomic information. Misregulation of the polo kinase is associated with cancers, thereby suggesting a link between defects in chromosome condensation and the formation of tumours. His scientific career soared when he published his team's findings showing that MAP kinase enzymes play an essential role in the cellular proliferation process. Binding a repellent at these receptors is believed to cause increased autophosphorylating activity of the CheA kinase. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. While several classes of kinase inhibitors are highly selective many possess a vast polypharmacology across the kinome target-scape. Erlotinib, gefitinib and afatinib inhibit tyrosine kinase at the epidermal growth factor receptor. Effect of actinomycin on thymidylic kinase activities of 24-hour regenerating liver supernatant fluid. Thymidine kinase DNA of TK6 human lymphoblast cells was analyzed using electrophoresis. Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. It preferentially hit tumor cells because the researchers had engineered the virus to lack an enzyme called thymidine kinase, which it needs. Show More Sentences Jakafi, an oral Janus kinase inhibitor, is FDA-approved for the treatment of patients with intermediate or high-risk myelofibrosis. Rhabdomyolysis is a musculoskeletal condition characterised by muscle weakness, an elevated creatine kinase level and myoglobinuria. Tie2 is a receptor tyrosine kinase expressed on vascular endothelial cells, which plays a key role in stabilizing blood vessels. With the advent of targeted therapy, specific tyrosine kinase inhibitors have been developed against the Ableson oncogene. This mutation encodes an enzyme, Bcr-Abl tyrosine kinase, that causes white blood cells to proliferate. Separation of tissue and serum creatine kinase isoenzymes by ion-exchange column chromatography. There was no elevation of creatine kinase levels, and the drugs did not appear to affect blood calcium, phosphate, or retinol concentrations. No abnormal serum electrolytes, urea nitrogen, creatinine, creatine kinase, and troponin-I were noted. Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase. Ganciclovir chemoablation of herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses. Desktop Profiler enables therapeutic research laboratories to conduct in-house kinase profiling in a timely and cost-effective manner. One of the immune system's strongest cellular defenses is protein kinase R, an enzyme that lies dormant until it detects viruses replicating within a cell. Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Proteins were extracted from these cells and assays were run to test the effect of the ECM and IGF-1 on fibroblasts by quantitating proteins for MAP kinase and Akt. Upon ligand binding, receptor homodimerization or heterodimerization occurs, which is followed by autophosphorylation and activation of the tyrosine kinase domains. Targeted therapeutics offer superior pharmacological benefits due to which profit margin of tyrosine kinase inhibitors are expected to increase in coming years. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Similar to BRAF and MEK inhibitors, ganetespib effectively suppressed the activity of ERK kinase in melanoma cells, a critical component in the BRAF signaling cascade. Age and gender specific pediatric reference intervals for aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin, and uric acid. Creatine is a naturally occurring metabolite that helps supply energy to all cells through creatine kinase reaction, including those involved in contraction of the heart. Show More Sentences Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. We also can test for thymidine kinase levels, which go up significantly when there is a rapid amount of cell division, a hallmark of cancer's growth. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Phosphorylation of both acetyl CoA carboxylase and AMP-activated protein kinase was increased, thus explaining the increase in fatty acid oxidation. Mitogen activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. IkT-001, a host-directed kinase inhibitor, is intended to clear JC polyomavirus infection, the causative agent of Progressive Multifocal Leukoencephalopathy. This region included the Polo-like kinase 4 gene which is responsible for mitotic spindle formation, providing a likely explanation for the findings. Two SNPs, rs14920313 and rs14920355, were located in the doublecortin-like kinase 1 gene, and rs313140585 was identified in the neurobeachin gene. Other tyrosine kinase inhibitors are evaluated as well, of which the Syk inhibitors, fostamatinib and entospletinib, might be of particular interest in the near future. Tonoplast-bound protein kinase phosphorylates tonoplast intrinsic protein. We report a case of HEV infection in an immunocompetent woman who had muscle-specific kinase antibody-positive myasthenia gravis associated with HEV replication. The RET proto-oncogene encodes a cell membrane receptor tyrosine kinase. In vitro and in vivo activity of protein kinase C inhibitor growth delay in vivo chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Characterization of sgk, a novel member of the serineAhreonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Examples from Classical Literature Eril prevents blood vessels from constricting with a new mechanism that inhibits the protein kinase, which is the last step in the vasoconstriction process. Find more words! 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Words that rhyme with kinase What is the plural of kinase? Use our Sentence Generator Nearby Words kinara kinaesthetic kina kin kimura kimonos Kincardine kincardineshire Kincardineshire Kinch kind kinda 6-letter Words Starting With k ki kin kina kinas