In most cell types DNA cleavage occurs after irreversible activation of endonucleases. |
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Some of the old codgers are probably in irreversible decline and the best years of their lives are certainly over. |
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Chronic inflammation can result in irreversible scarring of lung tissue, which impairs lung function. |
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The first antidepressant shown to be useful for SAD was the irreversible monoamine oxidase inhibitor phenelzine. |
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There is a growing belief among the geologists who study world oil supply that world oil production is soon headed into an irreversible decline. |
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These cells then enter a non-dividing state, termed senescence, which can lead to irreversible cell death. |
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We should not use a few examples of incredible recoveries from comas as evidence that there is no such thing as irreversible brain death. |
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But the worst thing about this neocon smash-and-grab job is that it's probably irreversible. |
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Because of the possibility of eventual neuronal death, the later neurologic consequences of pernicious anemia can be irreversible. |
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The intensity of the laser light is sufficient to vaporize material and produce irreversible changes. |
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Sulfuric acid applied to vegetable ivory causes an irreversible pink coloring in about 12 minutes. |
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This buck-passing, despite some valid observations, misses the common point that the momentum of market regulation is fundamentally irreversible. |
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When women take exogenous androgens, the same irreversible virilization occurs. |
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This developmental effect is irreversible, unlike the induction of vitellogenin in adults which ceases once estrogen exposure ends. |
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Then the president assured corporate America that his administration's repudiation of liberal reformism was irreversible. |
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Ozone is a toxic gas which in large quantities can cause irreversible damage to lung tissue and the respiratory tract. |
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Here physical time is understood as a stream of irreversible change that runs through physical space. |
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Do you think that our tourism industry is in permanent and irreversible decline, or do you think we will soon see the situation improve? |
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He allegedly was over sedated and consequently suffered cardiopulmonary arrest with an ensuing irreversible anoxic brain injury. |
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It seems that most sheep producers think as I do that the scheme is not only economically unattractive but also irreversible. |
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It would only take a few snap of his jaws and a few licks of his fingers for the thing to be done and irreversible. |
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The worst of all possibilities is if the patient has slipped into an irreversible coma due to a cerebral hemorrhage or some other catastrophe. |
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But parents should be mindful not to overdose their child as this results in more serious and irreversible conditions. |
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Mice fed a control diet consisting of mouse chow and no additional supplementation experienced irreversible platelet damage and premature death. |
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Only with time does it hydrolyze inside the epithelial cells of your lung tissue, causing increasing and irreversible damage. |
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Proteases are a class of hydrolytic enzymes mediating irreversible disruption of protein amide bonds. |
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Destruction of the alveolar walls, one of the pathologic changes in pulmonary emphysema, had been considered irreversible. |
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He argued that the earth resembled a closed system, which used up its finite stocks of useful energy in an irreversible way. |
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These cases of radiation sickness may, unfortunately, be irreversible and incontrovertible evidence of that. |
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The inhibitory compounds used for study are cytotoxic themselves, resulting in effects that are irreversible. |
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Will it mean that the tide of traditional patriarchal values, of conservative religiosity, will become irreversible? |
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Are we doing irreversible harm by giving our children fish fingers for tea? |
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His efforts need to be given momentum that is as irreversible as the economic reforms sweeping the country. |
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The future effects are unknown, but drug experts fear they may include irreversible brain damage or mental illness. |
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Although the plant has been mothballed, the damage done to Anjanwel is irreversible. |
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So the business people tend to take the short cut and thereby force the newspaper down an irreversible path. |
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Altering soil condition can be done in a short period of time, but please note that this is an irreversible process. |
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McKee explains that the swing must be at a maximum charge that's absolute and irreversible. |
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Speaking in Washington on the eve of an EU-US summit, Mr Prodi said the decision was momentous and irreversible. |
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The main aim of burns resuscitation is to increase tissue perfusion here and prevent any damage becoming irreversible. |
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Since the surgery is irreversible, the patients will experience less pain while resting. |
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I've forgotten about that wooden frame and only narrowly miss causing irreversible damage to my vertebrae. |
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All those empires were unsalvageable due to their infuriatingly irreversible histories. |
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The eye condition is irreversible and the study discovered that smoking was responsible for one in-five cases. |
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And though it looks attractive, it causes irreversible liver damage to horses and cattle which eat it. |
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If they become convinced they are wasting both time and resources, a pull-out will be swift and irreversible. |
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They seem to envisage an irreversible downward spiral leading to the depopulation of Australia. |
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Under the current system, most organs are donated by patients on life support machines who die after suffering irreversible brain damage. |
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In patients with DNA repair deficiencies anesthesia with enflurane may induce irreversible DNA damage. |
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Ultimately, in the third stage, this process becomes irreversible and leads to cell death. |
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A marriage before God is a sacrosanct thing, an act of union in the eyes of God, irreversible and permanent. |
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Prompt treatment with steroids may prevent further irreversible nerve damage. |
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The disease involves scarring of the lung, which causes an irreversible loss of the tissue's ability to transfer oxygen into the bloodstream. |
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She suggests that this approach is a theoretically consistent way to explain the cause of a wide variety of irreversible phenomenon. |
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Water putty, epoxies, construction glue and silicone sealants can cause irreversible damage to objects, he warned. |
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The result is an irreversible and progressive process of involution as death approaches. |
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His particular field of interest seemed to be where previously self-regulating systems underwent irreversible change. |
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We don't need the actresses of this world to tell us that beauty is only skin-deep or that, shock, horror, the ageing process is irreversible. |
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No one is safe as the accusations fly, sides are taken and irreversible decisions are forced to be made. |
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He was dialyzed for renal failure, and later diagnosed with irreversible renal failure. |
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Cotton production was obligatory as early as 1925 and had an irreversible influence on population movements and the politicization of residents. |
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Kantian ethics abstracts from the fact that as moral agents we are situated in the context of a history which is both unique and irreversible. |
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He is in such decline his defeat only emphasised that the tumble is irreversible. |
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By the time the miserable news hit the Millers like a blackjack on Sept. 24, the damage had been done and was irreversible. |
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In an annual such as Arabidopsis, flowering is irreversible, global, and leads to fruiting and plant death. |
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Its repeal is a matter of urgency before irreversible damage is done to the energy market, the economy as a whole and to democracy itself. |
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These bikes uproot heather and, if they run over Iron Age ancient burial mounds, the damage would be irreversible. |
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The three recent incidents cannot be bunched together to conclude that an irreversible rot has set in the police department. |
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The combat fatigue syndrome, which was expected to vanish with the passage of time, has proved to be chronic, if not irreversible in certain of its victims. |
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Patients with diabetes are probably more prone to irreversible rather than reversible ischaemic brain damage, and small lacunar infarcts are common. |
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Malignant cells incubated with nanoshells and exposed to the light source showed signs of irreversible heat damage and cell death, but control cells were left undamaged. |
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That border crossing will make a profound and irreversible difference. |
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This form is irreversible and leads to congestive heart failure. |
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At high enough stresses, irreversible processes accompany deformation. |
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The trauma of such ruptures in developmental trajectories was frequently expressed through descriptions of irreversible transformations of the identities of the victims. |
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If they are taking syrup of ipecac to induce vomiting, patients with the condition may suffer irreversible myocardial damage and can die of congestive heart failure. |
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Lead accumulates in the body and its effects are irreversible. |
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However, definitions which focus on the idea of either irreversible collapse or of bellows-like compression and rarefaction of air are no help in the present context. |
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By destroying trees and killing animals man may be able to fulfill his short-term desires, but he was causing a few irreversible problems in the long run. |
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The cause of death was septic shock and irreversible heart failure. |
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The reversible timelessness of the imagination distinguishes it from the irreversible chronometry of memory and bends it toward the creation of art. |
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However, the change in the photovoltage amplitude was at least reversible, and it seems likely that the change was not due to some irreversible denaturation. |
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That would create an irreversible cycle wherein the climate is beyond our control. |
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Bridges can be designed either to remain elastic during the design earthquake or to undergo irreversible but controlled deformation or displacement. |
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If I had my wish, football would suffer a sudden and irreversible drop in popularity. |
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At the cirrhotic stage, liver disease is considered irreversible. |
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Others discovered that after months or years of treatment they developed uncontrollable muscle twitches or tics that were often irreversible, even after stopping the drugs. |
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But again it would be inappropriate and unethical to use a placebo when the consequences of doing so would subject someone to the risk of serious or irreversible harm. |
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There is throughout more than a hint of the Joycean conceit that this process is giratory and sempiternal, even though its temporal vector may be historically irreversible. |
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After cardiac arrest, non-pregnant adults suffer irreversible brain damage from anoxia within three to four minutes, but pregnant women become hypoxic more quickly. |
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Surgical treatment, principally hysterectomy plus bilateral oophorectomy, is controversial because it is irreversible and associated with significant risks. |
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This analysis was run twice, once with all microstructural characters unordered, and a second time with the loss of laminar microstructures designated as irreversible. |
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The alkaloids in ragwort are very potent hepatotoxins and cause a characteristic form of liver damage which is irreversible and untreatable. |
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The rebellion was eventually suppressed, but the social changes it promoted were already irreversible. |
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Memorized information binds reversible microprocess within impulse with irreversible information macroprocess. |
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This behaviour had a profound and irreversible effect on the substrate which transformed the seabed ecosystems. |
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When two or three words are often used together in a particular sequence, the words are said to be irreversible binomials, or Siamese twins. |
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If the wreck stayed uncovered any longer it risked irreversible damage from biological decay and tidal scouring. |
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However, by the 1970s, the clothing industry was in irreversible decline, facing cheap foreign competition. |
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Adriamycin is used as a broad spectrum anticancer drug, but its irreversible cardiotoxicity greatly limits its clinical applications. |
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Age-related macular degeneration is the leading cause of irreversible vision loss in people over 65 in the United States. |
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A teenage burglar high on drugs beat up a 94-year-old widow and left her with irreversible brain damage, a jury was told yesterday. |
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From the pathophysiological point of view, respiratory failure occurs due to irreversible obstruction of the bronchiolar regions. |
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Now, a new mouthpiece may help protect players from irreversible harm. |
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Hearing impairment is the most frequent human sensory deficit and is mainly caused by the irreversible loss of neurosensory cells in the cochlea. |
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Demeaning the power of a sunblock cream is inviting irreversible trouble for your skin. |
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Thani was born in Khor Fakkan in 1962, a place that will have an irreversible and unerasable imprint on all his writings and experiences. |
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Lyophobic colloids are irreversible colloids or suspensoids, while lyophilic colloids are known as reversible colloids or emulsoids. |
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As chemotherapy often causes irreversible damage to the ovaries, one was removed and frozen. |
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Prompt therapy is necessary to avoid irreversible scarring, alopecia and depigmentation. |
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Here, Gregor has exhausted himself as a provider, and suddenly can work no more due to this irreversible illness. |
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Phenelzine and tranylcypromine are irreversible inhibitors of the monoamine oxidase enzyme. |
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The crisis has done irreversible harm to the countries' relations. |
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Pottier draws upon her years of graduate teaching for this study of linear irreversible processes within non equilibrium statistical physics. |
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The incidence of mechanical allodynia in patients with irreversible pulpitis. |
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In fact, I believe we should be setting out in legislation that the Scottish Parliament is permanent, it's irreversible, it's indissolvable. |
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There are many obvious ways to destroy information, one of which is thermodynamically irreversible processes. |
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In summary, the real estate industry is undergoing an irreversible historic shift to corporate organizations. |
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Left untreated, infection with intestinal worms can cause irreversible organ damage and impaired intellectual development. |
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Finally stumbling onto a rich vein, the three compatriots soon discover greed's insatiable and corrosive appetites, and Dobbs begins a slow, irreversible descent into madness. |
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In short, enough scientific evidence exists to cast doubt on the standard definition of brain death as the irreversible absence of all functions of the brain. |
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It benefits patients by preventing unnecessary invasiveness and compression which can cause irreversible damage which might not be detected until the recovery period. |
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Justice Commissioner Viviane Reding, who first proposed the law, said that the reform was a necessity, and now it is irreversible, PC World reports. |
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Whether the drugs work or not, the specter of addiction is very real, as is the potential for irreversible changes in nociceptor pathways within the central nervous system. |
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The administration of neuroleptics to these patients may lead to severe and irreversible extrapyramidal signs and in some cases the neuroleptic malignant syndrome. |
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However, unless misfile detection is performed during document preparation, pages can be microfilmed in the wrong sequence, in which case misfiles are irreversible. |
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These paints are converted from liquids with fine particles or micelles dispersed in them to solids through relatively abrupt, irreversible processes. |
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In 1990, while allegedly on a diet of 10 to 15 glasses of iced tea a day and little additional intake, Schiavo suffered cardiac arrest that caused irreversible brain damage. |
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However, patients who seek medical advice from a rheumatologist and receive treatment early will show reduced levels of irreversible joint damage. |
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Human diploid fibroblasts cultured under normal conditions have been reported to develop an irreversible cell cycle arrest, referred to as replicative senescence. |
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Severe cyanide poisoning, particularly during famines, is associated with outbreaks of a debilitating, irreversible paralytic disorder called konzo and, in some cases, death. |
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For study by methods of classical irreversible thermodynamics, a body is usually spatially and temporally divided conceptually into 'cells' of small size. |
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The damage done to Newfoundland's coastal ecosystem proved irreversible. |
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It suggesting that irreversible changes in signaling associated with osteoproliferation may play an important role in spinal radiographic progression. |
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But Montfort's decision to summon knights of the shires and burgesses to his parliament did mark the irreversible emergence of the landed gentry as a force in politics. |
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The clergy union argued that the penalty was unfair to victims of hypothetical miscarriages of criminal justice, because the ecclesiastical penalty is considered irreversible. |
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