How to use collagen in a sentence

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Sentence Examples In regular dense connective tissue, collagen bundles are arranged in a definite pattern, making the tissue greatly resistant to stress. These abnormalities are caused by defects in the genes that tell the cells how to make collagen. The adventitia is rich in collagen bundles, and contains some cells that may be fibroblasts or macrophages. Histologically, thick collagen bundles were seen, characteristically whorling around vessels in a fibrotic stroma. There were fascicles of spindle cells sometimes arranged in a whorled pattern or admixed with thick collagen fibers. Cells are laced with a network of fibres more rigid than the rope-like structural proteins collagen and keratin. The bones contribute albumen and collagen which convert to gelatine and give a good stew its gravitas. The beef has been sufficiently stewed to soften its collagen, making it delectably chewable. The driving force causing these alterations seems to be the increase in relative proportion of type III collagen. Three of the left-handed coiled collagen molecules form a right-handed coiled triple helix called tropocollagen. The cells of the outer annulus are thin and extended along the collagen fibrils, rather like tendon cells. The spindle cell areas showed extensive sclerosis with ropy, thick, osteoid-like collagen and microcalcifications. The concern that collagen injections can trigger autoimmune diseases like lupus is also unfounded, experts say. Ligaments, tendons and collagen depend on a steady intake of vitamin C to stay strong and healthy. Some manufacturers use animal-derived forms of collagen, such as ground-up chicken feet or the scrapings of bird or cow skins. Particles can stick to collagen fibrils or they can be hindered by the size of the mesh spacing between the fibrils. Dissection of chameleon tongues revealed an elastic collagen tissue sandwiched between the tongue bone and the accelerator muscle. Less expensive cuts such as brisket, silverside or topside have plenty of collagen, a protein present in connective tissues. Then there are chemical peels, microdermabrasion, laser hair removal, and the popular wrinkle filler, collagen. The thickness of subepithelial collagen fibrosis in the gastric biopsies stained with Masson trichrome was measured with an ocular micrometer. Show More Sentences Cells marked with similar colored dots moved collectively in the same direction forming domain-like structures on the collagen gel. These transmembrane molecules link the cell to laminins and collagen in the basal lamina. A practical limiting factor in forming more tightly crosslinked structures is the miscibility between the rose bengal amine and collagen. In our laboratory the trichrome stain was quite variable in its ability to stain the cytoplasm red and the collagen green. The researchers say the collagen allows the attachment of bioactive proteins that will promote healing and reduce clot formation. An example is collagen, for the biocompatible soft-tissue implants used to plump wrinkles. There is evidence that heating collagenous tissue causes tissue shrinkage through collagen denaturation. As we grow older, we all lose collagen, and therefore moisture from our skin. And thankfully there's not a collagen implant, Botox injection or tummy tuck to be seen. To relieve her anxieties, Wong, 26, turns to a collagen fortified drink and forces herself to eat more fruits. Most of the clients that take a seat in the make-up chair don't expect cosmetic help to the point of Botox or collagen injections. The duodenal mucosa showed severe villous atrophy but no subepithelial collagen deposition. The protein collagen is responsible for the tough qualities of connective tissue. As the tissue is heated, triple helical molecules rewind, shrinking the collagen fibers. Thick fibrous septa separated individual nodules and were composed of benign-appearing, spindle-shaped cells and collagen. The rejuvenating and vitaminizing process of the the collagen eye mask help to smooth the fine limes and the wrinkles around the eyes. There is also impairment of the platelet response to thrombin, collagen, fibrinogen, and von Willebrand factor. Thus, it seems unlikely that collagen was produced from pulp odontoblasts as in teeth. It had proved impossible to carbon-date the bone fragment accurately because of an absence of collagen from the sample. The elastic collagen fibres in the skin lose their elasticity, resulting in permanent loss of stretchiness and permanent wrinkling. Show More Sentences These include regulation of collagen synthesis, inflammatory cell chemotaxis, and DNA synthesis. To our knowledge we have characterized for the first time supramolecular aggregates of polyproline structures other than collagen. Nitric oxide stimulates collagen synthesis and subsequent healing at wound sites. In addition, three patients had hyaline collagen degeneration, four myxoid degeneration, three fibrinoid degeneration, and six had mixed lesions. The glucose in honey or derived from sugar may facilitate a balance between hyaluronic acid and collagen, similar to that found in fetal wounds. Bone consists of collagen banded fibrils sprinkled with tiny crystals of the mineral hydroxyapatite, which is basically calcium phosphate. Between two applications of collagen mask, apply the contents of one vial to thoroughly cleansed skin. Vitamin C is necessary for collagen formation, proper immune function, and as a tissue antioxidant. The collagen fibres are firmly embedded in the subchondral bone, giving stability to the cartilage. Without dietary vitamin C, the human animal cannot properly synthesize collagen. Among these, collagen is the major structural protein and is the most abundant in the human body. A protein called collagen leaks out from around the injured areas, causing inflammation. The cells were then implanted under the skin of mice where they produced collagen and other materials consistent with cartilage. Histologically, Peyronie's disease causes inflammation that results in collagen deposition and the formation of fibrous plaques. Accumulation of collagen and changes in its physiochemical properties contribute to the development of secondary complications of diabetes. Wall tissue is extensible when collagen fibers are folded, but nearly inextensible when collagen fibers near full extension. They were composed almost entirely of slender spindle cells haphazardly proliferating around bundles of dermal collagen. The skin of D. holocanthus is highly elastic because of microfolds in the epidermis and collagen fibers of the dermis. This application of topical nitric oxide may stimulate wound fibroblasts to increase collagen synthesis and remodeling. A dense band of fibroblasts, collagen fibers, proteoglycans, and occasional mast cells encase the granuloma. Show More Sentences Oral submucous fibrosis is a pre-malignant fibrotic condition of the mouth that exhibits excessive collagen production. In chronic hepatitis, it was strongly deposited at the margin of the fibrously enlarged portal areas where new collagen fibers were formed. As stated earlier, the duration of results from collagen injections is variable. It consists mainly of conjunctive collagen fibrils packed in lamellar bundles that are immersed in an amorphous ground fluid. New theropod integumental structures have been repeatedly dismissed as connective tissues, such as frayed collagen fibers or ossified tendons. They are arranged in bundles, separated by sheets of connective tissue containing collagen. This causes the skin's natural collagen to contract, usually reducing wrinkles over the following months. As collagen undergoes maturation and contraction, local forces give rise to further distension of air spaces. Gelatine, an animal by-product rich in collagen, was frequently used by Middle Age painters as a fixative to bind pigments to canvas or wood. Topical steroids can reduce inflammation, while ascorbic acid may promote collagen synthesis following alkali exposure. The other way is to inject collagen or fat to plump up the cords and bring them back to youthful suppleness. To quantitatively ascertain the isotropy of the collagen gels imaged with confocal reflectance microscopy, several approaches are used. Further, it has been described that the cross section of collagen fibrils contains central low density areas. This collagen solution was emulsified with an equal volume of Freund's incomplete adjuvant. Vitamin C is also an important nutrient for collagen production and provides immune system support. They also stimulate production of collagen and may enhance the action of antioxidants. A progressive deposition of proteins, proteoglycans, and collagen fibers occurs in lung interstitium, and interstitial fibrosis occurs. These are type IV collagen, heparan sulfate proteoglycans, entactin and laminin. Transmission electron microscopy reveals that the enamel of the lungfish dentition contains no collagen, nor does it stain with picrosirius red. Since gelatin is derived from collagen, it is composed of various amino acids. Show More Sentences The derm is is composed of fibroblasts, collagen, matrix proteins, and elastic fibers. Collagenase breaks down collagen, a major and rigid component of devitalized tissue. The original hematoma is replaced by granulation tissue with gradually increasing collagen content. In a related experiment, articular cartilage was incubated for two days with the enzyme elastase, which specifically digests the collagen fibers. They consist of thin sheets of collagen and smooth muscle with an endothelial covering. These cells are fed elastin, collagen, and hyaluronic acid from the dermis and their function is to filter out impurities and to provide a smooth appearance. Molecular chromophores besides melanin abound in the skin and include keratin, collagen, elastin, proteins, lipids, steroids and urocanic acid to name a few. In view of the elastic modulus of hydroxyapatite being at least three orders of magnitude larger than that of collagen, this seems to be quite natural. Designed silk-like materials have been made in this way, as well as protein-related synthetic materials similar to collagen and elastin, an elastic protein in skin. The plant chemical rutin, which is a flavonoid, is partly responsible for this and also helps to rebuild the collagen fibres that maintain the outer layers of the vessels. Among nonsurgical procedures, Botox injections top the list, followed by microdermabrasion, collagen injections, laser hair removal and chemical peels. However, independent of the degree of fibrosis and contracture, the fibrotic cords consist of collagen bundles oriented in the direction of the aponeurotic fascia. The nature, abundance and architecture of collagen and other fibres, like elastin and reticulin, are responsible for the tone, firmness and youth of our skin. When a wound occurs, a wide variety of structural and functional proteins such as proteoglycans, collagen and fibronectin are marshaled to the wound site. As the heat from the RF frequency stimulates the collagen, a cryogen spray is used to cool the outer layer of skin to tighten it up, and to prevent any burning effect. It is essentially composed of a type II collagen sponge supported by water held in place by proteoglycans produced by the chondrocytes embedded in the matrix. The fibrillar collagens also change across the disc, with the nucleus containing only type II collagen while both types I and type II are found in the annulus. At one point, I was encased in a jelly-green-tea collagen mask, which was awesome. Your ligaments, tendons, bones and skeletal muscles are all held together by collagen, as well as the smooth muscle tissue like your blood vessels, digestive tract and organs. The scientists noted that the tissue extracted from the mice had all of the hallmarks of normal bone, including organized collagen fibers and various mineralized components. Show More Sentences Other collagen diseases, such as progressive systemic sclerosis and systemic lupus erythematosus, are associated with increased incidence of pneumothorax. Figure 3 B shows an optical section at a depth 14 m into the sample, revealing intense SHG from a matrix of collagen fibrils in the epimysium layer surrounding muscle fibers. Bacterial attachment to inanimate surfaces generally requires that a surface be conditioned by organic deposits, such as collagen, laminin, fibrin, and fibrinogen. To create the custom-made ligaments, the harvested cells are cultured in vitro in a specially designed bioreactor with a collagen or other suitable biodegradable matrix. It's a permanent soft-tissue filler that is composed of part bovine collagen and part polymer beads, which help stimulate the body to produce its own collagen. The most commonly used neurite-promoting factors include collagen, laminin and fibronectin and the most extensively studied neurotrophic factor is nerve growth factor. The dermis also helps regulate collagen and elastin, protein fibers that keep skin soft, and help it to adjust its size to accommodate your growing body. At low strains the collagen fibers have almost random orientations. The tensile strength of collagen fibers is comparable to that of steel. Therefore, when collagen dissolves, necrotic tissue detaches and granulation can occur, providing the surface needed for proper epithelialization. Similar to collagen injections, it plumps up creases in the face. The morphologic changes such as decreased cell density, decreased collagen fibril density, and loss of fiber waviness that occur with aging predispose the tendon to injury. The middle layer, or dermis, contains connective tissue, small blood vessels, sweat and oil glands, nerves, and cells that produce collagen, called fibroblasts. Our group has also successfully demonstrated that the gel mixture of collagen, laminin and fibronectin could offer a suitable growth medium for the regeneration of axons. Again like all proteins in the body, collagen has a finite life span after which it is degraded to the constituent amino acids and replaced by new fibres. Laser treatments, microdermabrasion, chemical peels, collagen and Botox injections, light therapy and even medical acupuncture are being offered at a growing number of spas. We attempted to mimic a more biological situation by studying cells embedded in confluent monolayers which are grown on collagen or microcellulose-coated glass coverslips. The principle stress-bearing elements of the lung, which account for its tendency to recoil, are elastin and collagen fiber networks and surface tension. As the lesion grows, a fibrous cap made of collagen and elastin walls off the lesion from the lumen of the artery to protect the arterial lumen from the atheroma. Collagen fibrils are well known to be assemblies of parallel collagen molecules arranged with a longitudinal stagger according to the Hodge-Petruska scheme. Show More Sentences This beef is marbled yes, but with tiny threads of collagen, which are not to be confused with the conjunctive tissues found in other types of beef. Efficacy and safety of glycosylated undenatured type-II collagen in therapy of arthritic dogs. The biologically derived materials are segmented into, xenogenic tissue and collagen. Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis. Effects of reduced join mobiliy on sarcomere length, collagen fibril arrangement in the endomysium, and hyaluronan in rat muscle. Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone. This luxurious rejuvenator balances skin pH levels and builds collagen with peptides. Gene expression and protein distribution of collagen, fibronectin and laminin in bovine follicles and corpora lutea. The impact of intermolecular collagen cross-links in bone has been adduced, in part, from studies of lathyrism. The individual collagen fibrils are strengthened by inter-molecular cross-links that develop as a natural part of their maturation process. What makes collagen a kind of supermolecule, however, is its three-dimensional triple helix architecture. To assess the quality of the collagen in the samples, the carbon to nitrogen ratio was evaluated. Histology showed dense collagen bearing a small cyst lined by reactive synovium and containing some fibrin but no evidence of neoplasia is seen. Prolonged use of this ingredient thickens collagen fibers, resulting in ochronosis. It measures an octapeptide fragment of type I bone collagen that is released into circulation upon osteoclastic bone resorption. When the ratio of collagen is disbalanced, decreases the ventricular wall compliance, increases stiffness, and diastolic filling is limited. Corneal Cross-Linking can strengthen the cross-links between collagen fibers that keep it strong and able to retain its normal shape. This basically makes collagen by exfoliating your face like mad and using a little sun lamp. One of the ways to increase the manufacture of collagen is to supplement with a highly bioavailable form of silica. Odanacatib inhibits cathepsin K, the primary protease in osteoclasts that breaks down bone collagen during bone resorption. Show More Sentences They secrete collagen fibres on to the newly eroded bone surface, forming a protein matrix called osteoid. Vitamin C aids the body in making collagen, which helps create new bone, blood vessels, ligaments, and tendons. Microcarriers materials may be composed by natural polymers and their derivative such as glutin, collagen, fibrin, chitin, dextran or cellulose. Perimysial collagen crosslinks and meat tenderness in Belgian Blue double-muscled cattle. Hemidesmosome formation, which was observed along the collagen fibres and extensions, was demonstrated. Dental hemostats are sub-divided into gelatin based hemostats, oxidized regenerated cellulose based hemostats and collagen based hemostats. When the macrophages are finished cleaning up damaged ligaments, fibroblasts, cells that produce collagen and elasticin, rebuild the ligaments. In doing so the outer layer is encouraged to produce new collagen and elastin which generates new skin cells to repair itself. This active deswelling maintains the organization of collagen fibers implicated in crystal-clear corneal transparency. Masson's trichrome staining was also done to assess the collagen formation. No reduction in albuminuria, glomerulosclerotic index or cortical collagen deposition was observed. Tranilast has also been reported to inhibit the synthesis of collagen by fibroblasts from keroid and hypertrophic scar as well as normal scar. As meat cooks, the structure and especially the collagen breaks down, allowing juice to come out of the meat. Jellyfish are also harvested for their collagen, which can be used for a variety of applications including the treatment of rheumatoid arthritis. The upper dermis showed a perivascular and periadnexal infiltrate of lymphocytes, while a large amount of mucin was seen among collagen bundles. Among other materials found in the bone was collagen, as in the Tyrannosaurus bone. The collagen fibers give bone its tensile strength, and the interspersed crystals of hydroxyapatite give bone its compressive strength. Lamellar bone also requires a relatively flat surface to lay the collagen fibers in parallel or concentric layers. The extracellular matrix of bone is laid down by osteoblasts, which secrete both collagen and ground substance. These synthesise collagen within the cell, and then secrete collagen fibrils. Show More Sentences While bone is essentially brittle, bone does have a significant degree of elasticity, contributed chiefly by collagen. Humans and certain other animals require vitamin C in their diets to make the building blocks for collagen. In the synthesis of collagen, ascorbic acid is required as a cofactor for prolyl hydroxylase and lysyl hydroxylase. These two enzymes are responsible for the hydroxylation of the proline and lysine amino acids in collagen. Contract awarded for acellular dermal acquisition of implant natural collagen and elastin fibers hydrated saline, moh no. Retinol penetrates the outer layers of the skin and repairs damage to the lower layers, where collagen and elastin are found. Corneal collagen cross-linking with riboflavin and ultraviolet light is a relatively new treatment option for keratoconus. A connective tissue, basement membranes sit outside cells and are composed of ropes of collagen and other large molecules. Biological hydroxylations and ascorbic acid with special regard to collagen metabolism. Effects of NSAIDs on collagen and proteoglycan synthesis of cultured chondrocytes. Therefore, the adhesive role of type XIV collagen may interact with type I collagen, PRELP and angiomotin. Through the radio frequency both the dermis and hypodermis skin layers are affected safely to regenerate new collagen and shrink fat cells. Injections of an obscure cell best known for making collagen might quell the runaway inflammation that underlies lethal sepsis. Multiple nests can form an alveolar pattern and be surrounded by collagen and dense fibrous septae. Below that, there's the dermis, This layer is a complicated matrix of connective tissue, collagen fibrils and microfibrils. Silicotic nodules were defined as discrete lesions with smooth, sharp borders and concentric laminated collagen fibers. Cartilage cells were extracted from the patient's nasal septum, multiplied and expanded onto a collagen membrane. The vitamin is a cofactor for the synthesis of collagen, the predominant protein in skin. But you don't have to be a Hollywood insider to try this new line of high-end collagen products. The identity of the folks who concocted the collagen glue remains uncertain. Show More Sentences Though the ingredient can cause slight flakiness, it works by increasing the activity of enzymes in the skin that produce collagen. Effect of umbelliferone on tail tendon collagen and haemostatic function in streptozotocin-diabetic rats. Today, however, natural casings are often replaced by collagen, cellulose, or even plastic casings, especially in the case of industrially manufactured sausages. The ELASTIderm Wrinkle Reducing Lotion is formulated with a proprietary bi-mineral complex with malonic acid that helps replenish elasticity and build collagen. In conclusion, this pilot study showed that tracheal dilation with balloon cryotherapy decreased collagen deposition in the injured airway of 1 animal. As a comparison with abalone, red meat muscle tissue consists of contractible myofibrils assembled into parallel fibrous bundles interconnected by collagen. That's why we've developed our new vegan-friendly formula with collagen precursors that provide additional nutritional support for the body to make its own healthy collagen. In some cancer patients, it actually causes collagen buildup in the skin. Right and left ventricular collagen content was increased with pulmonary artery banding compared to sham-operated controls and ameliorated by macitentan. Following incubation, tissue samples were confirmed for high collagen content through Masson-Trichrome staining and tested by rheometry to measure stiffness. Estee Lauder Resilience Lift Face and Neck Cream, PS60 This daily moisturiser supports skin's natural production of collagen and elastin to volumise and tighten skin. When collagen is missing or defective, body parts where connective tissue is most important, such as skin, joints, and blood vessels, behave abnormally. CartiGram, an optional application available on GE's Signa line of MR scanners, allows clinicians to noninvasively visualize collagen fiber degradation. Masson's trichrome staining showed that there were no collagen fibers in the interlobular and portal areas, and few collagen fibers in the central veins and sinusoidal. The SDS-PAGE gel of HMD and BDDGE treated group, which depicted characteristic bands of collagen, was used as a model to assess the antibody binding in the immunoblot. Common findings were dilated stacks of rough endoplasmic reticulum, polyribosomes, randomly distributed intermediate filaments, and rare collagen secretion granules. This study demonstrated that proanthocyanidin did not affect cell proliferation but significantly increased collagen synthesis by cultured fibroblasts. Dog and Cat foods containing animal origin ingredients other than milk, fish, gelatin, and collagen and dicalcium phosphate are restricted from entering the domestic markets. Plating fibroblasts on Laminin induced the greatest response to IGF-1, and production was diminished on low concentrations of collagen and plastic. The new product, which contains fish collagen, hyaluronic acid, chondroitin sulfate, elastin, ceramide, vitamin C, B2 and B6, helps maintain the skin condition. Show More Sentences Biochemical markers of bone formation by Osteocalcin and Bone-ALP and resorption by N-terminal collagen type 1 and C-terminal collagen type 1 for bone turnover were assessed. In this disease, there is formation and deposition of antibodies against the alpha-3 chain of type IV collagen along glomerular and alveolar basement membranes. A major element of scar tissue is that collagen cross-links and forms an alignment in a single direction rather than the irregular basketweave pattern in normal tissue. Hydrolysing this macromolecule sufficiently to reduce its MW substantially, depending upon manufacturing protocols, results in a collagen that becomes much more soluble. In childhood, the causes of severe eosinophilia are parasitic infections, allergic disorders, malignant diseases, and some collagen tissue diseases. The collagen fibres rapidly polymerise to form collagen strands. The mineralised matrix of bone tissue has an organic component of mainly collagen called ossein and an inorganic component of bone mineral made up of various salts. Thusly treated intertubular dentin surfaces comprise a hydrated layer of exposed collagen fibrils that are substantially attached to underlying mineralized dentin. The type of collagen an animal has in its bones varies according to its DNA and, in both cases, this collagen was of the same type found in modern chickens and ostriches. Ovarian fibroma is a solid tumor that belongs to sex-cord stromal cell tumors of the ovary and comprises spindle shape fibroblastic cells and abundant collagen. Although we observed that collagen strongly induced the aggregation of platelets to potentially cause coronary microembolization, GH did not enhance thrombogenicity. The laser stimulates new collagen and remodels scar tissue so stretchmarks shrink and smooth out, although expect an improvement rather than outright cure. In 2007 and again in 2009, Schweitzer and colleagues used chemical and molecular analyses to confirm that the fibrous material collected from the specimens was collagen. Examples from Classical Literature By boiling with water, dilute acids or dilute alkalies, collagen is split up into gelatin or glutin. As goatskins are so tight fibred, a longer liming and a greater loss of collagen is permissible than with most pelts for chrome. Gelatine contribute largest share to the global collagen market, with its major application in food sector. A blinded pathologist graded histologic sections of the injured tracheas for collagen content. It damages collagen and dermatologists say they can spot a smoker just by looking at the crinkly skin on their chest. Histologic examination of the tumour showed spindle-shaped cells arranged in short fascicles with abundant thick bundles of hyalinized collagen. The main part of protein film is a protein collagen, which has fibred structure with hard enough separate fibers. Because collagen makes up the fibrils that anchor the two skin layers together, Uitto's team concludes that dominant dystrophic EB results from the collagen mutation. Women will do almost anything to stave off wrinkles but I gave a wry smile when I read that a collagen drink was a bestseller at a chain of high-street chemists. They are a good source of vitamin C, which as well as warding off colds and flu, assists in making collagen, which keeps the skin looking youthful. Find more words! 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Words that rhyme with collagen What is the plural of collagen? What is the adjective for collagen? What is the noun for collagen? Use our Sentence Generator Nearby Words collaged collage collaborators collaborator collaboratively collaborative efforts collagenase collagenous collagens collages collaging collagist 8-letter Words Starting With c co col coll colla collag collage