| We have emphasized the positive feedback and activation processes in autocrine relays. |
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| Growth factors are intercellular signaling molecules that regulate cell proliferation by autocrine and paracrine mechanisms. |
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| Among the system properties governing the transition from nonpolarity to polarity a prominent parameter is the rate of autocrine ligand release. |
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| The amount of ligand that has been released by the autocrine cell in response to the activation is insufficient in this case to sustain signaling. |
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| In particular, spatially localized autocrine signaling may confer directional persistence to cell migration, as suggested by recent experimental observations. |
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| Here, we systematically derive discrete models of cell-to-cell communication from a mechanistic description of autocrine and paracrine signaling in epithelial layers. |
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| Vasopressin could be an autocrine hormone in the olfactory epithelium. |
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