| Liposomal formulations of genetic drugs such as antisense oligonucleotides and plasmid DNA are difficult to achieve. |
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| The sense and antisense RNAs are complimentary and the strands will readily bind together to form a duplex. |
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| The company retains the right to practice its licensed antisense patent technologies and to sublicense it to collaborators. |
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| The genotypes were confirmed by sequencing both sense and antisense strands using forward and reverse primers in separate reactions. |
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| Such mutants have been generated by chemical mutagenesis, gene disruption, and antisense gene silencing. |
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| In the long run, I fully expect gene therapy and antisense to fix what can be fixed at the genomic level. |
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| However, this leaves a problem, namely which gene in a pair of bidirectional protein-coding genes should we consider the sense gene and which the antisense? |
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| Broken arrows indicate starts of sense and antisense transcription. |
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| Minimally modified phosphodiester antisense oligodeoxyribonucleotide directed against the multidrug resistance gene mdrl. |
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| A single anti-microRNA antisense oligodeoxyribonucleotide targeting multiple microRNAs offers an improved approach for microRNA interference. |
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| This paper discusses the technology of antisense oligonucleotides as an example of the latter approach. |
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| Thirteen per cent of boys with DMD could be treated with this specific 'antisense' gene therapy, the largest group by a single antisense. |
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| Antisense molecules are tiny pieces of DNA or RNA designed to bind to a cell's own DNA or RNA and interfere with its activity. |
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| In both prokaryotes and eukaryotes, antisense RNA sequences are produced, but the functions of these RNAs are not entirely clear. |
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| The resulting antisense compounds shut down the cellular factory churning out a disease-causing protein. |
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| A second patent in Europe related to antisense RNA is expected to be issued this year. |
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| The sense strand yielded 1 characteristic peak pattern, while the antisense strand yielded 2-3 characteristic peak patterns. |
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| Loomis of the University of California, San Diego, used antisense genes in a slime mold to investigate cell specialization and movement. |
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| The most promising therapeutic approaches are nonsense mutation read-through and antisense oligonucleotide-induced exon skipping. |
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| NeuBiotics are antisense antibiotics composed of relatively short NEUGENE antisense polymers covalently linked to bacteria-permeating peptides. |
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| Ion exchange chromatography takes advantage of several aspects unique to antisense drugs. |
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| Wild-type plants treated with ancymidol, an inhibitor of GA biosynthesis, will tuberize in LD, which is very similar to the formation of tubers on the antisense PHYB plants. |
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| In contrast, AVI's third-generation NEUGENE chemistry has been developed over the past 14 years to overcome the pitfalls of the other antisense backbone chemistries. |
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| A few DNA sequences in prokaryotes and eukaryotes, and more in plasmids and viruses, blur the distinction between sense and antisense strands by having overlapping genes. |
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| Smith and Cleveland administered the antisense inhibitor intraperitoneally and intraventricularly to rodents expressing SOD1 over a period of weeks. |
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