How to use amyloid in a sentence

Looking for sentences and phrases with the word amyloid? Here are some examples.

Sentence Examples These so-called amyloid deposits accumulate extracellularly in various organs. All eyes studied that had characteristics of amyloid accumulation by hematoxylin-eosin staining were also stained with Congo red. The simultaneous occurrence of random aggregation and amyloid fibril formation has been observed before. Amyloidosis is a functional disorder marked by unusual depositions of amyloid protein in various organs. This case is unique because of the massive deposition of amyloid in the spleen, adrenal gland, and liver. These plaques are formed when enzymes clip off and part of a protein called amyloid. Amyloidosis occurs when the protein amyloid is deposited in the kidneys under conditions other than ordinary. The three types of fibrils chosen for investigation represent extremes of precursor proteins that self-assemble into amyloid. Among four cases with primary pulmonary lymphoma, amyloid was observed in three cases as a minor finding. It seems that a fundamental similarity and parallel exists between the aggregation of lipoproteins and amyloid proteins. Such protofilaments merge and intertwist, yielding thin fibrils, which are capable of further association and twining, producing mature amyloid. Earlier studies indicated that the fibrils themselves were the cytotoxic form of amyloid peptides. Bronchiolar diseases and amyloid and malignant lymphoma were seen less frequently. The first and more predominant structure was a mesh of filaments measuring 10 to 15 nm in diameter, which is typical of amyloid. Specifically, the pressure-induced growth of the circular insulin amyloid suggests anisotropic packing within an ambient protofilament. It is characterized by squamous epithelial cells, calcifications, and eosinophilic deposits that have been identified as amyloid. In the human skin, amyloid is found in close connection with the sweat glands and sebaceous glands, which display a great functional activity. Once activated, microglia become concentrated in the regions of amyloid beta deposits where they are able to infiltrate the plaques. A major prediction of the Radical Model is that glycine residues should be important for the neurotoxicity of the amyloid beta peptide. Stability in the alpha helices, even if it decreased the overall stability of the protein, inhibited the formation of amyloid fibrils. Show More Sentences The common herpes simplex virus HSV-1 has been found to colocate with amyloid plaques. Of those, only one both blocks egg-laying and causes amyloid protein to build up in mammalian cells. Their working hypothesis is that the low-grade infection causes inflammation, which in turn causes the amyloid to start gumming up. Modulatory approaches which protect neurons will be identified and tested directly in vivo using injection of amyloid beta into rat brain. Thus, the kidneys, after many injections of the protein, showed the characteristic macroscopic picture of the third stage of the amyloid nephrosis. However, increased aluminum exposure in people already developing amyloid plaques may hasten neuronal death. The brains of these mice develop amyloid plaques and the mice are memory-impaired. Abnormal deposits of the protein amyloid are believed to be involved in the pathology of the disease. However, for many patients such efforts are unsuccessful and amyloid formation continues. New vaccines that will eliminate amyloid but not have the dangerous side effects of the first vaccines. Researchers unknowingly used a stain containing aluminium to color the amyloid plaque found in the brain of Alzheimer's disease. Here, the blockage of RNA prevents extra amyloid from being produced by targeting its precursor protein and making less of it. They have chemical and toxicological properties quite different from either single beta amyloid molecules or clumps of the molecules called fibrils. Most researchers think the disease is caused by the build-up of beta amyloid. If any of these got prioritized and funded to the extent of amyloid, we might be a lot closer to getting a drug than we are now. Dr Lipton found that amyloid beta spurred the astrocytes to release large amounts of glutamate. He and his colleagues added amyloid beta to cultures of astrocytes, a common type of brain cell that helps support neurons. Many types of protein may congeal into amyloid plaques, and such plaques can form in a number of different tissues. In studies of class I hydrophobin rodlets it has been estimated that the rodlet diameters range from 2 to 15 nm, which is also within the range of some other amyloid proteins. Thanks to these tracers, scans can detect amyloid plaques in the brain of someone who is still alive. Show More Sentences Hiapp belongs to the group of amyloidogenic proteins, characterized by their aggregation and deposition as fibrillar amyloid in various body tissues. The presence of amyloid confirmed histologically by either Congo red or sulfonated Alcian blue stains or by electron microscopy was seen in 8 muscles. A particular form of amyloidosis characterized by the deposition of amyloid in the brain is associated with Alzheimer disease. Role of glycogen synthase kinase-3? in the Regulation of Production and Toxicity of amyloid? It is not known whether activated microglia are responsible for, or a result of amyloid beta plaque pathology. Acute effects of amyloid peptides onpresynaptic cholinergic neuron function. Amyloidosis is a heterogeneous group of disorders in which amyloid substances are deposited extracellularly. Carpal tunnel syndrome, subcutaneous amyloid deposition, macroglossia, cardiomyopathy, and nephropathy are other clinical manifestations. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Characteristic plaques in the brain consist primarily of amyloid beta, although there are other protein deposits in the brain such as neurofibrillary tangles. The presence of neurofibrillary tangles and senile plaques in the brain and amyloid deposits around cerebral blood vessels are characteristics of Alzheimer's patients. By this time, those close to Robin were becoming aware of symptoms of the rare neurological condition amyloid angiopathy, which was, slowly, to rob him of his cognitive powers. Preliminary data show that two promising PET amyloid radiotracers, developed at our PET Centre, bind well to the amyloid protein aggregates and with desirable fat solubilities in live animals and humans. One part of the research plan is to use amyloid beta, the primary component of senile plaques in AD, to activate calcium signalling pathways in cultured human microglia. However, the critical point of principle made by Professor Mallucci's study is that a drug, given orally, can arrest neurodegeneration caused by amyloid in the brain. These are made of a protein called tau, which, like amyloid, occurs in normal nerve cells, but in Alzheimer's disease it becomes chemically altered and piles up as thread-like tangles impairing tau's key roles in nerve cells. ProteoTech is a leader in the field of proteoglycan and amyloid disease research and development. He has come up with a way that proteins and RNA might catalyse each other's production. The protein involved would crystallise in the form of long, and easily formed, fibres called amyloid. Amyloidosis is a group of conditions of diverse causes characterized by the accumulation of amyloid in various organs and tissues of the body such that vital function is compromised. Studies have shown that presenilin was involved in a metabolic pathway leading to the production of the neurotoxic amyloid peptide, which accumulates in the brain of patients with Alzheimer's disease. Show More Sentences He has ankylosing spondylitis, a chronic inflammation of the spine, which has caused deposits of a mysterious substance called amyloid throughout his body. Rather, the stable alpha helices inhibited the types of interaction that would otherwise lead to amyloid formation. It has been known for a long time that mutations in a protein can encourage amyloid formation. Dr Kelly has now shown that atheronals can, at least in a test tube, trigger the sort of misfolding in amyloid proteins which is believed to lead to the formation of plaques. Many researchers believe that the amyloid deposits not only make the nerve cells sick, but they somehow promote the development of tangles, and it is probably these that actually kill the nerve cells. Or, if Wischik is right, beta amyloid has been the wrong focus all along. The malformed protein molecules then tangle up to form amyloid plaques. Abeta aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. In general, the deposition of amyloid may be either localized or systemic and either primary or secondary. He waits occasionally until amyloid degeneration, or, as Mr. Barwell prefers to call it, lardaceous degeneration, is far advanced, and then the case is considered hopeless. The potential utility of this model in the identification of new inhibitors of amyloid formation will be tested using low molecular weight heparin mimetics that have already shown promise as anti-amyloid drug candidates. The expression and catalytic activity of neural endopeptidase which is involved in degrading beta amyloid was also measured. In Alzheimer's patients a protein, beta amyloid, misforms into plaques that destroy neurons, vital fibres in the brain that allow thinking and memory. This unique vaccine approach is based on soluble, synthetic homologues of the human amyloid toxin, which were found to be highly immunogenic when tested in animals. The pathologic features of amyloid deposits include beta-pleated sheet structures that are composed of amyloid fibrils with diameters between 8 to 10 nm. In heart muscle, clusters are formed of desmin amyloid proteins. In this study, we found that pitrilysin, a zinc metallopeptidase of the inverzincin family, degrades monomeric, but not oligomeric, islet amyloid polypeptide in vitro. Systemic amyloid light chain amyloidosis is a condition in which the amyloid protein is abnormally deposited in the extracellular matrix of multiple organs. The company's three lead, late stage products are for treatment of sickle cell anemia, transthyretin familial amyloid polyneuropathy, and neurocysticercosis. Cerebral amyloid angiopathy, which is a disorder involving intracranial microangiopathological lesion, is the main cause of secondary subarachnoid hemorrhage in the elderly. The most common pathological features of GSS include numerous amyloid plaques, spongiform changes, neuronal loss, astrocytic microgliosis, and neurofibrillary tangles. Show More Sentences Specifically, using DNAVEC's proprietary Sendai virus vector, they plan to develop a gene vaccine that can selectively induce the production of anti-beta amyloid antibodies. It is believed that stabilization of transthryetin will inhibit further amyloid deposition and stop progression of the disease in FAP and FAC patients. Examples from Classical Literature The amyloid material is remarkable for its power to resist the action of chemical agents and putrefactive decomposition. As is well known, the amyloid material itself resists the action of the gastric juice. The liver, besides the change due to cirrhosis, may be affected by amyloid or fatty degeneration, or by both combined. He records three cases in which the amyloid deposits ensued in six, five, and three months, respectively. The corpora amylacea, so called, differ materially from starch-granules, and still more from the amyloid matter. However, it has been rendered probable that the amyloid deposit has close affinities with fibrin. A rare case of localised AA-type amyloidosis of the ureter with spheroids of amyloid. Yet some researchers now suggest that this so-called amyloid hypothesis is overstated and that other entities, including tau tangles, are as important as beta-amyloid. Also, in relevant animal models of Alzheimer's disease, the Mindset vaccine was shown to inhibit the deposition of toxic amyloid fibrils and to improve cognition. Find more words! 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What is the adjective for amyloid? What is the noun for amyloid? Use our Sentence Generator Nearby Words amylic amylase amylaceous amyl amygdaloidal amygdaloid amyloid-beta amyloidosis amyloids amylopectin amyloplasts amylopsin 7-letter Words Starting With a am amy amyl amylo amyloi