| In contrast, phase II metabolism, including acetylation, sulfonation, conjugation, and glucuronidation, is little changed with aging. |
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| Important mechanisms for epigenetic alteration of gene expression include DNA methylation and histone acetylation. |
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| Thus it not only had nucleosomes and histone acetylation and methylation, but was also sexual with meiosis and a bouquet stage. |
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| Slowly, as researchers learned more about the structure of histones, it became evident that patterns of acetylation and methylation could be quite precise. |
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| This effect is consistent with the expected large reduction in electron density on the amino nitrogen upon acetylation thus making coordination with copper much less strong. |
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| Isoniazid is metabolized in the liver mainly by acetylation and dehydrazination. |
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| The acetylation of 5-ASA takes place in the liver and the gastrointestinal wall of the colon independently of the acetylator status. |
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| Fast acetylation of isoniazid may produce high concentrations of hydrazine which facilitates deflorination of enflurane. |
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| The acetylation of salicylic acid increased the potency of morphine by making the compound more soluble in brain fat and facilitating transfer across the blood brain barrier. |
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| As shown in Figure 17a, hydroxyl groups in the amorphous wood polymers are replaced with acetyl groups by acetylation, whereas the formaldehyde treatment introduces oxymethylene bridges between the wood polymers. |
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| Rats that had experienced little maternal care showed high levels of methylation and low levels of acetylation of the glucocorticoid-receptor gene and its neighbouring proteins. |
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| That suggests it is the acetylation of H3 histones rather than the methylation of DNA itself that is creating the effect. Which crucial genes these histones surround remains obscure. |
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| The rate of acetylation is genetically determined. |
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| Covalent modification of histone proteins through acetylation and deacetylation affects chromatin structure and regulates gene expression. |
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| Chemical modifications of these basic amino acid residues include methylation, phosphorylation, and acetylation. |
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| They include posttranslational modifications such as tyrosination, acetylation and glutamylation, as well as MT growth, pausing and shortening. |
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| In the affected mice, those genes also had much lower levels of acetylation and expression. |
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| Phosphorylation, methylation, acetylation, and ubiquitination are primary modifications of lysine and serine residues on histone tails. |
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| Gelatinisation temperatures and enthalpy reduced on acetylation and diminished further as the acetyl group increased. |
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| Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos. |
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| Gerard Collette, the president of Rhodia Acetow, said this will allow the company to build on its acetylation know-how in the field of cellulose acetate. |
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| In recent years, at least eight different types of covalent modifications, such as acetylation, methylation, or ubiquitylation, have been described on histone tails. |
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| Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. |
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| Levels of urinary Ni and global H3K4 trimethylation, H3K9 acetylation, and H3K9 dimethylation were measured in peripheral blood mononuclear cells. |
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