| It then flows past the villages of Matlock Bath, Cromford, Whatstandwell, and Ambergate, where it is joined by the River Amber. |
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| Below Ambergate, the river flows by the town of Belper and the villages of Milford and Duffield, where it is joined by the River Ecclesbourne. |
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| Between Ambergate and Cromford, the river, road and railway are also paralleled by the Cromford Canal. |
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| The MR made a takeover offer only to discover that a shareholder of the GN had already gathered a quantity of Ambergate shares. |
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| The river also indirectly supplies Carsington Reservoir, with the water taken from the river by a pumping station at Ambergate in times of high flow. |
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| The former Midland Railway's lines from Derby to Sheffield and Manchester also followed the Derwent, the former as far as Ambergate and the latter as far as Rowsley. |
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